It is recommended that patients who experience tablet residue in the stool and no improvement in their condition should be switched to a different clarithromycin formulation (e.g. Quantity. At 250 mg b.i.d. Amoxicillin 500 mg is prescribed for a variety of infectious diseases caused by bacteria: inflammation …. Your doctor may need to change your treatment plan if you use any of the following drugs:To make sure this medicine is safe for you, tell your doctor if you have ever had:an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).In animal studies, clarithromycin caused birth defects. Available for Android and iOS devices. Pharmacology, adverse reactions, warnings and side effects. For patients with creatinine clearance <30 mL/min, the dose of clarithromycin should be decreased by 75% using an appropriate clarithromycin formulation. Slightly higher incidences of abnormal values were noted for patients who received 4000mg daily for all parameters except White Blood Cell.Reporting suspected adverse reactions after authorisation of the medicinal product is important. Clarithromycin prescription and dosage sizes information for physicians and healthcare professionals. When suggestions are available use up and down arrows to review and ENTER to select. Concomitant administration of clarithromycin and colchicine is contraindicated (see section 4.3).Caution is advised regarding concomitant administration of clarithromycin and triazolobenzodiazepines, such as triazolam, and intravenous or oromucosal midazolam (see section 4.5).Prolonged cardiac repolarisation and QT interval, imparting a risk of developing cardiac arrhythmia and torsades de pointes, have been seen in treatment with macrolides including clarithromycin (see section 4.8). suspension) or another antibiotic.Special population: Adverse Reactions in Immunocompromised Patients (see section e).Clinical trials have been conducted using clarithromycin paediatric suspension in children 6 months to 12 years of age.Therefore, children under 12 years of age should use clarithromycin paediatric suspension.Frequency, type and severity of adverse reactions in children are expected to be the same as in adults.In AIDS and other immunocompromised patients treated with the higher doses of clarithromycin over long periods of time for mycobacterial infections, it was often difficult to distinguish adverse events possibly associated with clarithromycin administration from underlying signs of Human Immunodeficiency Virus (HIV) disease or intercurrent illness.In adult patients, the most frequently reported adverse reactions by patients treated with total daily doses of 1000 mg and 2000mg of clarithromycin were: nausea, vomiting, taste perversion, abdominal pain, diarrhoea, rash, flatulence, headache, constipation, hearing disturbance, In these immunocompromised patients, evaluations of laboratory values were made by analysing those values outside the seriously abnormal level (i.e. The organisms include Clarithromycin 500mg twice daily and lansoprazole 30mg twice daily should be given with amoxycillin 1000mg twice daily.Clarithromycin 500mg twice daily and lansoprazole 30mg twice daily should be given with metronidazole 400mg twice daily.Clarithromycin 500mg twice daily and omeprazole 40mg daily should be given with amoxycillin 1000mg twice daily or metronidazole 400mg twice daily.Clarithromycin 500mg twice daily and omeprazole 20mg daily should be given with amoxycillin 1000mg twice daily..In pateints with renal impairment with creatinine clearance less than 30 Ml/min, the dosage of clarithromycin should be reduced by one- half, i.e. The major clinical signs at toxic doses included emesis, weakness, reduced food consumption and weight gain, salivation, dehydration and hyperactivity. 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