Examples include certain antiarrhythmics, such as those of Class 1A (such as quinidine, disopyramide and procainamide) and Class III (such as amiodarone and sotalol), tricyclic antidepressants (such as amitriptyline), certain tetracyclic antidepressants (such as maprotiline), certain antipsychotic medications (such as phenothiazines and pimozide), certain antihistamines (such as terfenadine); lithium, quinine and pentamidine. Therefore, concurrent use of these drugs with clomipramine is not recommended (see section 4.4). Therefore, hypokalaemia should be treated before initiating treatment with clomipramine (see section 4.5).Before initiating treatment it is advisable to check the patient's blood pressure, because individuals with hypotension or a labile circulation may react to the drug with a fall in blood pressure.Due to the risk of serotonergic toxicity, it is advisable to adhere to recommended doses. This should be attained gradually over a period of 2 weeks starting with 1 x 25 mg clomipramine daily. Our website services, content, and products are for informational purposes only. We comply with the HONcode standard for trustworthy health information - How long does minocycline take to work? Purpose: We determined whether clomipramine taken as needed increases ejaculation latency in men with premature ejaculation and controls. The quantity of unchanged clomipramine and desmethylclomipramine excreted in the urine amounts to about 2% and 0.5% of the administered dose respectively.In the elderly, plasma clomipramine concentrations may be higher for a given dose than would be expected in younger patients because of reduced metabolic clearance.The effects of hepatic and renal impairment on the pharmacokinetics of clomipramine have not been determined.Phospholipidosis and testicular changes considered to be secondary to the phospholipidosis, commonly associated with tricyclic compounds, have been observed with clomipramine hydrochloride at doses Clomipramine hydrochloride demonstrated evidence of embryotoxicity No teratogenic effects were detected in mice, rats, and rabbits at doses up to 100, 50, and 60 mg/kg, respectively.The administration of clomipramine hydrochloride to mice and rats for 104 weeks did not show any evidence of carcinogenicity at dose levels representing 16 - 20 times the estimated oral MRHD of 5 mg/kg on a mg/kg basis.Packs of 5, 7, 10, 14, 15, 20, 21, 25, 28, 30, 56, 60, 84, 90, 100, 112, 120, 168 and 180 capsules in either:1) Polypropylene containers with tamper evident polythylene caps and optional use of polyethylene ullage fillerBuilding 4, Trident Place, Mosquito Way, Hatfield, Hertfordshire, AL10 9ULTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. Monitoring therapeutic response of tricyclic antidepressants at high dose oestrogen regimens (50 micrograms daily) is recommended and dose adjustments may be necessary.This drug may also increase plasma concentrations of tricyclic antidepressants, whose dosage should therefore be reduced.Concomitant administration of valproate with clomipramine may cause inhibition of CYP2C and/or UGT enzymes resulting in increased serum levels of clomipramine and desmethylclomipramine.Concomitant administration of Clomipramine with grapefruit, grapefruit juice, or cranberry juice may increase the plasma concentrations of clomipramine.Rifampicin (CYP3A and CYP2C inducer), may decrease clomipramine concentrations as concomitant administration of drugs known to induce cytochrome P450 enzymes, particularly CYP3A4, CYP2C19 may accelerate the metabolism and decrease the efficacy of clomipramine.Concomitant administration of ion exchange resins such as cholestyramine or colestipol may reduce the plasma levels of clomipramine. 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