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Genetic Implication. 0000008407 00000 n
Clozapine is available as tablets taken by mouth. epilepsy; clozapine-induced agranulocytosis, severe granulocytosis, chemotherapy, coma, leukemia, leukopenia, neutropenia,
B); older adults. 0000019649 00000 n
Strikethrough Discontinued. 0000001344 00000 n
myocarditis, concurrent administration of benzodiazepines or other psychotropic drugs; renal failure, dialysis, hepatitis,
An antipsychotic agent other than clozapine would be preferred due to the possibility of clozapine-induced agranulocytosis or other adverse events in the nursing infant; guidelines support that lactating women taking clozapine should not breastfeed. If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Brand Name: Clozaril, FazaClo, Gen-Clozapine (CAN) Classification: Antipsychotic (Dopaminergic blocker) Pregnancy Category B. 7 0 obj <>
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Also has anticholinergic and alpha-adrenergic blocking activity. 0000019451 00000 n
Initial therapy: 12.5 mg PO once or twice daily. CAPITALS indicate life-threatening, underlines indicate most frequent. In particular whilst there were a number of different contributing factors key themes included junior medical staff confidence in prescribing clozapine and nursing staff were not always aware of the implications of delaying clozapine for more than 48 hours. To reduce recurrent suicidal behavior in schizophrenic patients.Binds to dopamine receptors in the CNS. Contact your institution's library to ask if they subscribe to McGraw-Hill Medical Products. Dosage & Route Adults. Incidents investigations by nursing leads however identified lower awareness levels within medical and nursing staff. To reduce recurrent suicidal behavior in schizophrenic patients.Binds to dopamine receptors in the CNS. Get Free Access Through Your Institution
Document the number, duration, and severity of seizures, and report these findings immediately to the physician.Monitor and report signs of myocarditis, including unexplained fatigue, dyspnea, tachypnea, fever, chest pain, palpitations, ECG changes (ST-T wave abnormalities), tachycardia, and other arrhythmias. This div only appears when the trigger link is hovered over. Mechanism is not defined.
Produces fewer extrapyramidal reactions and less tardive dyskinesia than standard antipsychotics but carries high risk of hematologic abnormalities. Get Free Access Through Your Institution
Report these signs to the physician immediately. 0000000836 00000 n
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neurological disease, tardive dyskinesia, previous history of agranulocytosis; surgery, glaucoma, infection, pregnancy (category
Safety and efficacy in children have not been established. Arrhythmias, GI disorders, narrow-angle glaucoma, hepatic and renal impairment, prostatic hypertrophy, history of seizures;
Using clozapine with other drugs that make you drowsy or slow your breathing can cause dangerous side effects or death. This div only appears when the trigger link is hovered over. Report these signs to the physician immediately.Assess motor function, and be alert for extrapyramidal symptoms.