Female mice given 150
the progression of lesions to the crusted and healed stages, and decreased the
5 times a day (dosing appropriate for treatment of genital herpes). Ann Intern Med
additional studies were performed at the HGPRT locus and at the
Herpes simplex andvaricella-zoster specified thymidine kinase transform acyclovir to itsmonophosphate which is then transformed by a number of cellular enzymes toacyclovir diphosphate and acyclovir triphosphate. Plasma levels in both males and females at all dose levels after one
Warnings. thymidine kinase with altered substrate specificity. infections. Huff JC, Bean B, Balfour HH, Jr., Laskin OL, Connor
male and 8 female mice per group (dosed in the same manner) after the first and
implantation efficiency or litter size.In a rat peri- and postnatal study (20 female rats per
mg/mL.Acyclovir was tested for mutagenic activity in cultured
mg/kg/day, testicles were normal in dogs at 50 mg/kg. with supernumerary ribs in all drug-treated groups. Therefore, the patient’s dosing schedule should be adjusted so that an additional dose is administered after each dialysis.No supplemental dose appears to be necessary after adjustment of the dosing interval.Zovirax Suspension was shown to be bioequivalent to Zovirax Capsules (n = 20) and 1 Zovirax 800-mg tablet was shown to be bioequivalent to 4 Zovirax 200-mg capsules (n = 24).Zovirax Capsules (blue, opaque cap and body) containing 200 mg acyclovir and printed with “Prestium Zovirax 200”Zovirax Tablets (light blue, oval) containing 800 mg acyclovir and “Zovirax 800”Zovirax Tablets (white, shield-shaped) containing 400 mg acyclovir and engraved with “Zovirax” on one side and a triangle on the other side.Zovirax Suspension (off-white, banana-flavored) containing 200 mg acyclovir in each teaspoonful (5 mL).Zovirax is a registered trademark of GlaxoSmithKline.2013 Delcor Asset Corporation, an affiliate of Prestium Pharma, Inc.See prescribing information for dosage information.Do not use if black printed safety seal under cap is broken or missing.Dispense in a tight container as defined in the USP.See prescribing information for dosage information.Do not use if printed safety seal under cap is broken or missing.Dispense in a tight container as defined in the USP.See prescribing information for dosage information.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. no morphologic or functional evidence of adverse effects on developing brain or
However, 200
VIII Int Conf
852 (females only). Urinary excretion and renal clearance were correspondingly reduced.In a study of patients who received Zovirax 400 mg twice daily for 3 years, 45%, 52%, and 63% of patients remained free of recurrences in the first, second, and third years, respectively. Drennan DP, Gooze L et al. additive. increase mortality in the neonatal period.Rats in the low-dose group gained as much body weight as
reproduction in groups of 15 male and 30 female mice in a two-generation
Susceptibility of vaccine strains of varicella-zoster virus to antiviral
numbers of live fetuses and implantation sites at 12.5 mg/kg/day and 25 mg/kg/day
there were no drug-related reproductive effects.In a subchronic toxicity study where groups of 20 male
Kurtz T. Safety and efficacy of long-term suppressive
At 50 mg/kg/day s.c. there was a statistically
last 800 mg dose were 2.8 μg/mL (2.3 to 3.1 μg/mL) and 1.8 μg/mL
Englund JA, Zimmerman ME, Swierkosz EM, Goodman JL,
The dams were not treated. significant decrease in implantation efficiency but no concomitant decrease in
kinase of altered substrate specificity that is able to phosphorylate the
number of Acyclovir was tested for mutagenic activity in the Ames
listed in Table 2.Evidence so far from clinical trials suggests that the
per day during organogenesis.A teratology study was done in New Zealand White rabbits