One uses cyclophosphamide to kill cells that are causing harm, usually cancer cells or inflammatory cells.This potent cell-killing medication is a “nitrogen mustard” derivative, meaning it is related to the toxic chemical weapon “mustard gas” (so named because of its “mustard” or “horseradish” odor) used widely in the first World War. In chemotherapy, cyclophosphamide is classified as an “alkylating agent” which means it works by binding to DNA, and interfering with normal cell function. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It can also be given as an injection in the hospital setting. MRSP Dogs and Spaying. Keeping your Pet Healthy and Happy. 3,12–15 Although doxorubicin has been evaluated as a single agent for lymphoma in dogs, cyclophosphamide has not. How It Works. Both the median overall survival time and the median disease-free interval in dogs treated with LDC were 178 days. Cats undergoing chemotherapy commonly lose their whiskers. When it occurs, it is generally readily controllable with antinauseal medications.Up to 30% of dogs (depending on the study) receiving cyclophosphamide for over 2 months develop bloody urine caused by excretion of irritating cyclophophamide metabolites. Cyclophosphamide and piroxicam are used together to address some sarcomas in dogs as a means of addressing the tumor with reduced potential for the side effects listed below.There are several important side effects to consider when using cyclophosphamide:White cell blood lines show suppression (i.e. Cells that divide rapidly (and thus replicate their DNA rapidly) are especially targeted by cyclophosphamide. Neutering your Male Dog. Keeping your Pet Healthy and Happy. This condition may represent pre-cancer in itself and must be distinguished from a bladder infection. Store liquid forms in the refrigerator in a glass container for up to 14 days.Any overdose, no matter how small, should be considered an emergency. Cells that divide rapidly (and thus replicate their DNA rapidly) are especially targeted by cyclophosphamide. Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … The waste and gloves should be disposed of in a plastic bag deposited in the regular trash. Cyclophosphamide is an immunosuppressive agent that can be used for a variety of conditions in both dogs and cats. Gradual improvements are usually noticeable after a few days.If you miss a dose, contact your veterinarian for further instructions, as this medication must be dosed very carefully.Side effects include hair loss or changes in hair coat. By disrupting cellular DNA, cyclophosphamide is able to kill the cell. Examples of such medications include Diuretics of the thiazide class may increase the bone marrow suppression side effects of cyclophosphamide. This is a serious side effect of cyclophosphamide use and any sign of bloody urine should be reported to the … counts will drop) approximately 1-2 weeks following a dose of cyclophosphamide. This condition may represent pre-cancer in itself and must be distinguished from a bladder infection. Cyclophosphamide has been created for use in humans, but it is also used in veterinary medicine.The drug is marketed as Cytoxan or Neosar and will be applied in dogs with cancerous tumors and autoimmune diseases. CYC can be combined with a non-steroidal anti-inflammatory drug (NSAID) such as piroxicam, for its potential ant-cancer effect on … Cyclophosphamide is used to treat various types of cancer.It is a chemotherapy drug that works by slowing or stopping cell growth.. Cyclophosphamide also works by decreasing your immune system's response to various diseases. Ten percent of dogs in the current study also developed hemorrhagic cystitis, a known complication of cyclophosphamide therapy in dogs. Common side effects include hair loss and hair coat changes. In chemotherapy, cyclophosphamide is classified as an “alkylating agent” which means it works by binding to DNA, and interfering with normal cell function. Cats undergoing chemotherapy commonly lose their whiskers. Up to 30% of dogs (depending on the study) receiving cyclophosphamide for over 2 months develop bloody urine caused by excretion of irritating cyclophophamide metabolites.