what does it mean or indicate? The most common adverse events with diclofenac sodium topical solution are application site reactions. Children may be prescribed diclofenac to treat joint problems. Most spontaneous reports of fatal GI events are in elderly or debilitated patients and therefore, use special care when treating this population.To minimize the potential risk for an adverse GI event, use the lowest effective dose for the shortest possible duration. However, severe hepatic reactions can occur at any time during treatment with diclofenac. Most adults can take diclofenac. ( NSAID medicines should not be used by pregnant women late in their pregnancy.What are the possible side effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?Get emergency help right away if you have any of the following symptoms:Stop your NSAID medicine and call your healthcare provider right away if you have any of the following symptoms:Call your doctor for medical advice about side effects. Ocular. It is not completely understood how reduced synthesis of these compounds results in therapeutic efficacy.Diclofenac, the active component of diclofenac sodium topical solution has anti-inflammatory, anti-nociception, and antipyretic effects.After topical administration to healthy human volunteers of single and multiple maximum doses of diclofenac sodium topical solution, 40 drops (approximately 1.2 mL) to each knee (80 drops total dose), the following diclofenac pharmacokinetic parameters were obtained: (see But drinking too much alcohol may irritate your stomach.Try to keep to the recommended guidelines of no more than 14 units of alcohol a week. Diclofenac sodium topical solution is contraindicated in the perioperative setting of coronary artery bypass graft (CABG) surgery Therefore, do not use combination therapy with diclofenac sodium topical solution and an oral NSAID unless the benefit outweighs the risk and conduct periodic laboratory evaluations.Diclofenac sodium topical solution cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency. There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. Instruct patients who are pregnant or intending to become pregnant not to use diclofenac sodium topical solution Please try again with another drug. For details see our Our clinical information is certified to meet NHS England's Information Standard.Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals.© Patient Platform Limited. Applies to diclofenac ophthalmic: ophthalmic solution. Apply a thin layer and gently massage it into the affected area.Wash your hands after applying the gel (unless you are treating your hands).Solaraze® and Solacutan® gels contain diclofenac, which is a Coronavirus: how quickly do COVID-19 symptoms develop and how long do they last?Coronavirus: what are asymptomatic and mild COVID-19?Coronavirus: what are moderate, severe and critical COVID-19?What are the differences between colds, flu and COVID-19?COVID-19: how to tell hay fever and coronavirus apartAre any coronavirus home remedies safe or effective?Is losing your sense of taste and smell a symptom of coronavirus?There are other brands of diclofenac gel manufactured too, but these are used to treat painful muscle and joint conditions - they are not interchangeable with Solaraze® or Solacutan®. For more details, please use our Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. NSAIDs, including diclofenac sodium topical solution cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Diclofenac sodium is contraindicated in the setting of coronary artery bypass graft surgery. Physicians and patients should remain alert for the development of such events, even in the absence of previous CV symptoms. The quarterly trend chart illustrates changing levels of adverse events over time. If your healthcare provider has prescribed diclofenac sodium topical solution for both knees, repeat steps 2 and 3 for the other knee.Wash your hands with soap and water right away after applying diclofenac sodium topical solution. Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occur in approximately 1% of patients treated for 3 to 6 months, and in about 2 to 4% of patients treated for one year. Why do I need to be careful about stomach ulcers? NSAID medicines are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as:These are not all the side effects with NSAID medicines. This may indicate that they could enhance the toxicity of methotrexate.