Antihistamines appear to compete with histamine for cell receptor sites on effector cells.Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Some reports may have incomplete information.Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. The molecular formula is C Diphenhydramine hydrochloride USP in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride USP per mL. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. In the young pediatric patient, particularly, they may produce excitation.Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients.Diphenhydramine hydrochloride has an atropine-like action and, therefore, should be used with caution in patients with a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease or hypertension. II, 185-189(1990). It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com. Diphenhydramine injection is also used alone or along with other medications to control abnormal movements in people who have Parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance). Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. Retain in carton until time of use.Keep this and all drugs out of the reach of children.We comply with the HONcode standard for trustworthy health information - Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.Diphenhydramine hydrochloride should not be used in neonates and premature infants (see Diphenhydramine hydrochloride injection may diminish mental alertness, or, in the young pediatric patient, cause excitation. Drug interactions are reported among people who take Benadryl and Cialis together. Selected from data included with permission and copyrighted by First Databank, Inc. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. All rights reserved. Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur.THIS PRODUCT IS FOR INTRAVENOUS OR INTRAMUSCULAR ADMINISTRATION ONLY.Diphenhydramine hydrochloride in the injectable form is indicated when the oral form is impractical.Divide into four doses, administered intravenously at a rate generally not exceeding 25 mg/min, or deep intramuscularly.10 to 50 mg intravenously at a rate generally not exceeding 25 mg/min, or deep intramuscularly, 100 mg if required; maximum daily dosage is 400 mg.Sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride USP in a 1 mL amber color glass vial with yellow bands and white OPC mark, and available in packages of twenty-five packed in a PVC rondo tray in a single carton.Use these dosage charts for infants and children under 12 years old:The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. There are, however, no adequate and well-controlled studies in pregnant women. Biopharmaceutics & Drug Disposition, Vol. Benadryl Injection - Clinical Pharmacology. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Benadryl in the injectable form has a rapid onset of action. Overdosage may cause hallucinations, convulsions, or death (see Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Diphenhydramine hydrochloride USP is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. Drug interactions are reported among people who take Benadryl and Cialis together. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82. Available for Android and iOS devices. Detailed information on the pharmacokinetics of Diphenhydramine Hydrochloride Injection is not available.Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.Because of the risk of local necrosis, this drug should not be used as a local anesthetic.Hypersensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.Antihistamines should be used with considerable caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, or bladder-neck obstruction.Local necrosis has been associated with the use of subcutaneous or intradermal use of intravenous diphenhydramine hydrochloride injection.In pediatric patients, especially, antihistamines in As in adults, antihistamines may diminish mental alertness in pediatric patients.