My friend sent me a link to to tis site. They affect the filtration and concentration of the circulating blood volume. Carbonic anhydrase inhibitors are rapidly absorbed and widely distributed and are excreted in the urine. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Your message goes here Further reabsorption of sodium occurs in the loop of Henle and lastly in the distal tubule, where sodium is exchanged for potassium. As the intravascular fluid reduces and becomes more concentrated, the oncotic pull increases, drawing fluid from the interstitial spaces back into the circulation, reducing oedema.All diuretics produce a similar effect, although their modes of action may differ (see diagram, opposite page).There are five classes of diuretics: thiazides and thiazide-like diuretics; loop diuretics; carbonic anhydrase inhibitors; potassium-sparing diuretics; and osmotic diuretics.Thiazide: Thiazide diuretics, such as bendroflumethiazide and chlortalidone, inhibit the reabsorption of sodium and chloride in the distal tubule of the nephron. They work by blocking the chloride pump, inhibiting the active pumping of chloride out of the tubule and the associated passive movement of sodium back into the circulation.They are used to treat oedema associated with congestive heart failure (CHF) or with liver and renal failure. Asked 10 Jun 2013 by blaidlaw Updated 10 June 2013 Topics high blood pressure, thyroid disease, blood pressure, thyroid Renal disease 5. ��ࡱ� > �� M ���� a b ���������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������� R �������� ��d�O��� � �)� �K݂��� P i c t u r e s ���� ���� �v P o w e r P o i n t D o c u m e n t ( ���� ���� C \: S u m m a r y I n f o r m a t i o n ( ���� c �� �������������������� The onset of diuresis is rapid (within minutes with IV administration) and may extend for over six hours (Hopkins, 1999).Potassium-sparing diuretics are well absorbed, protein bound and widely distributed. 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