Thus, it has been recommended that the prothrombin time should be carefully monitored in patients taking warfarin sodium who subsequently begin high-dose paracetamol treatment [ 1 ]. Settipane RA, Stevenson DD "Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma." The study is created by eHealthMe based on reports of 17 people who take Coumadin and Pepcid complete from the Food and Drug Administration (FDA), and is updated regularly. We comply with the HONcode standard for trustworthy health information - O'Dell JR, Zetterman RK, Burnett DA "Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic." Pepcid and Protonix are similar in that they both help reduce acid production. Am J Med 96 (1994): 3-915. Eur J Clin Pharmacol 38 (1990): 389-9043. Therapeutic excess: Excessive paracetamol taken with intent to treat pain or fever and without self-harm intent. In this capacity, she has been paid, and continues to be paid, by a wide range of organisations for providing these skills on a professional basis. Management of intravenous paracetamol overdose is not covered.BMJ Best Practice would like to gratefully acknowledge the previous team of expert contributors, whose work has been retained in parts of the content:DKC and AN declare that they have no competing interests.Honorary Clinical Senior Lecturer in Clinical PharmacologyNational Poisons Information Service (Newcastle unit)RT was an investigator in the Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning (SNAP) study. Hepatology 19 (1994): 1141-826. Ann Pharmacother 33 (1999): 1191-4Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. N Engl J Med 330 (1994): 1907-834. RT declares that he has no other competing interests.SM works as a freelance medical journalist and editor, video editorial director and presenter, and communications trainer. Bougie DW, Benito AI, Sanchez-Abarca LI, Torres R, Birenbaum J, Aster RH "Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen." Anaesthesia 47 (1992): 789-9111. Ann Intern Med 87 (1977): 302-420. The researchers say that when warfarin and paracetamol were detected simultaneously, the number of fatal bleeds was 4.6 and 2.7 times higher than with paracetamol or warfarin alone, respectively ( P <0.05). Gursoy M, Haznedaroglu IC, Celik I, Sayinalp N, Ozcebe OI, Dundar SV "Agranulocytosis, plasmacytosis, and thrombocytosis followed by a leukemoid reaction due to acute acetaminophen toxicity." Blood 109 (2007): 3608-944. Guccione JL, Zemtsov A, Cobos E, Neldner KH "Acquired purpura fulminans induced by alcohol and acetaminophen - successful treatment with heparin and vitamin-k." Arch Dermatol 129 (1993): 1267-946. http://www.ncbi.nlm.nih.gov/pubmed/21508044?tool=bestpractice.com Tell care providers that you take warfarin before you have any medical or dental procedures. J Pharm Sci 81 (1992): 203-724. Singer AJ, Carracio TR, Mofenson HC "The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction." Minton NA, Henry JA, Frankel RJ "Fatal paracetamol poisoning in an epileptic." New Guidelines Urge OTC Painkillers, Not Opioids Other drugs may affect Pepcid Complete, including prescription and over-the-counter medicines, vitamins, and herbal products. It is important that the level of COUMADIN in your body remains consistent. Paracetamol is often recommended as one of the first treatments for pain, as it's safe for most people to take and side effects … J Intern Med 253 (2003): 95-84. Includes registration requirements and pharmacovigilance.A practical guide to influencing the availability of medicines, and policies of their use. “Paracetamol is often considered a safer option since there is no stomach irritation or effect on the platelets,” they said. N Engl J Med 331 (1994): 1310-121. This can be very dangerous while you are on Coumadin. Protonix is more powerful, and if you are having pain while on this medication it is a very worrisome sign. High levels of alcohol consumption can alter the way the body metabolizes warfarin. Paracetamol is predicted to increase the risk of methaemoglobinaemia when given with topical prilocaine. 2011 Apr 19;342:d2218. Van Diem L, Grilliat JP "Anaphylactic shock induced by paracetamol." Expert Review Panel" 2. Ann Pharmacother 30 (1996): 762-55. 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