Doxepin does not seem to induce CYP isoenzymes. Therefore, to prevent a delay in onset of action and to minimize the likelihood of daytime sedation, doxepin should not be taken within 3 hours of a meal.Doxepin is metabolized primarily by the liver’s cytochrome P450 (CYP) 2C19 and CYP2D6 enzymes; CYP1A2 and CYP2D6 are involved to a lesser extent. The pharmaceutical drug Silenor (doxepin) is a tricyclic antidepressant that is also used as a hypnotic to initiate and maintain sleep. Doxepin (Silenor) is in a class of medications called tricyclic antidepressants. Do not take this medication unless you are able to get a full night of Dosage is based on your medical condition, age, and response to therapy. Uses All patients received all treatments, and each treatment was followed by 8 hours of polysomnography (PSG) evaluation in a sleep laboratory. If you wake up too soon, you may feel drowsy from the medicine. Use the lowest effective doxepin dose in these residents. Do not store in the bathroom. Low-dose doxepin—3 mg and 6 mg—has demonstrated efficacy for insomnia characterized by frequent or early-morning awakenings and an inability to return to sleep (). It works by increasing total sleep time and improving sleep quality. Keep all Do not flush medications down the toilet or pour them into a drain unless instructed to do so. This medication is used to treat a certain sleep problem ().It may help you stay asleep longer and reduce the number of times you awaken during the night. Peak plasma time: 2 hr Downloaded from the American Family Physician Web site at … It was approved by the FDA for the treatment of insomnia in March 2010. Learn more about Doxepin (Sinequan) at EverydayHealth.com. Doxepin is excreted in urine primarily as glucuronide conjugate.Coadministration with cimetidine, an inhibitor of CYP isoenzymes, could double the doxepin plasma concentration; therefore, patients taking cimetidine should not exceed 3 mg/d of doxepin.Doxepin reduced insomnia symptoms in 3 pilot studies at doses of 10, 25, and 50 mg, and in 2 phase III randomized, double-blind, placebo-controlled clinical trials using 1, 3, and 6 mg In the first phase III trial, 67 patients, age 18 to 64 with chronic primary insomnia, were randomly assigned to placebo or 1 mg, 3 mg, or 6 mg of doxepin for 2 nights. The antidepressant effect of doxepin is thought to result from inhibition of serotonin and norepinephrine reuptake at the synaptic cleft. Doxepin is also available as a capsule and liquid to treat depression and anxiety. It comes in an easy-to-administer capsule and may help improve quality of life. Customers may receive this drug under the names Sinequan, Silenor. Properly discard this product when it is expired or no longer needed. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment.This survey is being conducted by the WebMD marketing sciences department.All information will be used in a manner consistent with the WebMD This monograph only gives information about doxepin (Silenor) for insomnia. Do not take the medicine unless you can get a full night's sleep (7 to 8 hours). To help you remember, take it at the same time each day.Tell your doctor if your condition persists or worsens after 7-10 days.Rarely, after taking this drug, people have gotten out of bed and driven vehicles while not fully awake ("At higher doses, doxepin is used to treat a variety of other conditions, including Get medical help right away if you have any very serious side effects, including: This is not a complete list of possible side effects. 1 FDA-approved in March 2010, doxepin (3 mg and 6 mg) is only the second insomnia medication not designated as a controlled substance and thus may be of special value in patients with a history of substance abuse.