Therapeutic Class: Benign Prostatic Hypertrophy Agent. A post-hoc analysis of this study showed a higher incidence of the composite term cardiac failure in subjects taking Dutasteride and an alpha blocker concomitantly (12/1152, 1.0%), compared to subjects taking Dutasteride and no alpha blocker (18/2953, 0.6%), placebo and an alpha blocker (1/1399, <0.1%), or placebo and no alpha blocker (15/2727, 0.6%) (see section 4.4). In a small study (N=24) of two weeks duration in healthy men, dutasteride (0.5 mg daily) had no effect on the pharmacokinetics of tamsulosin or terazosin. E-Mail: azinfo@astrazeneca.com. This information is intended for use by health professionalsEach soft capsule contains lecithin (which may contain soya oil)The capsules are opaque, yellow, oblong soft gelatin capsules filled with an oily and yellowish liquid, without printing.Soft capsules dimensions are: 19 ± 0.8 mm x 6.9 ± 0.4 mmTreatment of moderate to severe symptoms of benign prostatic hyperplasia (BPH). Dutasteride is considered to be a practically insoluble (in water) and relatively neutral molecule. … The difference between the groups was statistically significant from Month 1 to Month 24. The higher incidence of adverse events in the combination therapy group in the first year of treatment was due to a higher incidence of reproductive disorders, specifically ejaculation disorders, observed in this group. Telefon: 0 41 03 / 70 80. We comply with the HONcode standard for trustworthy health information - There was also no indication of a pharmacodynamic interaction in this study Dutasteride capsule is contraindicated for use by women. … This can cause problems with urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely.Dutasteride blocks the action of an enzyme called 5-alpha-reductase. In volunteer studies of dutasteride, single daily doses of dutasteride up to 40 mg/day (80 times the therapeutic dose) have been administered for 7 days without significant safety concerns. hergestellt von: … The additional 2-year follow-up study of the REDUCE trial did not identify any new cases of Gleason 8–10 prostate cancers.In a 4 year BPH study (CombAT) where there were no protocol-mandated biopsies and all diagnoses of prostate cancer were based on for-cause biopsies, the rates of Gleason 8-10 cancer were (n=8, 0.5%) for Dutasteride, (n=11, 0.7%) for tamsulosin and (n=5, 0.3%) for combination therapy. Telefax: 0 41 03 / 708 32 93. In a separate 4-year study in 8231 men aged 50 to 75, with a prior negative biopsy for prostate cancer and baseline PSA between 2.5 ng/mL and 10.0 ng/mL in the case of men 50 to 60 years of age, or 3 ng/mL and 10.0 ng/mL in the case of men older than 60 years of age) (the REDUCE study), there was a higher incidence of the composite term cardiac failure in subjects taking Dutasteride 0.5 mg once daily (30/4105, 0.7%) compared to subjects taking placebo (16/4126, 0.4%). Dutasteride partitioning from serum into semen averaged 11.5%. Total serum PSA levels return to baseline within 6 months of discontinuing treatment. Dutasteride was not studied in patients with liver disease. The following table shows adverse reactions from controlled clinical trials and post-marketing experience. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Following oral dosing of dutasteride 0.5 mg/day to steady state, 1.0% to 15.4% (mean of 5.4%) of the administered dose is excreted as unchanged dutasteride in the faeces. Available for Android and iOS devices. Uses for dutasteride. Physicians should instruct their patients to promptly report any changes in their breast tissue such as lumps or nipple discharge. Small amounts of dutasteride have been recovered from the semen in subjects receiving dutasteride 0.5 mg a day. Evidence that dutasteride does not inhibit/induce CYP2C9 or the transporter P-glycoprotein have sex.Along with needed... Cancers is not affected by food away during treatment with dutasteride treated males of... Cause birth defects in male fetuses carcinogenicity did not show any particular risk humans... Can be considered if side effects tamsulosin at Month 48 b almost time for your next dose, throat.Dutasteride. 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