Famciclovir is an antiviral medicine that is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles.
None of the children in Study 2 had genital herpes.There are no pharmacokinetic and safety data in children 1 to <12 years of age to support a famciclovir Testicular changes included Famciclovir had no effect on general reproductive performance or fertility in female rats at doses up to 1000 mg/kg/day At 25°C famciclovir is freely soluble (>25% w/v) in water initially, but rapidly precipitates as the sparingly soluble (2%-3% w/v) monohydrate. No clinically significant effect on penciclovir pharmacokinetics was observed following multiple-dose (three times daily) administration of famciclovir (500 mg) with multiple doses of digoxin.Concurrent use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.The conversion of 6-deoxy penciclovir to penciclovir is catalyzed by aldehyde oxidase. Treatment was initiated within 72 hours of first lesion appearance and was continued for 7 days.In the placebo-controlled trial, 419 patients were treated with either FAMVIR 500 mg three times daily (n=138), FAMVIR 750 mg three times daily (n=135) or placebo (n=146).
The half-life in 17 patients with herpes zoster was 2.8±1.0 hours and 2.7±1.0 hours after single and repeated doses, respectively.Based on cross study comparison, penciclovir AUC was 40% higher and penciclovir renal clearance was 22% lower in elderly subjects (n=18, age 65-79 years) as compared with younger subjects. The active ingredient in FAMVIR tablets is famciclovir, an orally administered prodrug of the antiviral agent penciclovir. Famciclovir is most effective if started at the earliest sign or symptom of a cold sore (such as tingling, burning, itching, pain, or lesion). The efficacy and safety of famciclovir have not been established as suppressive therapy in infants following neonatal HSV infections. The median time to healing of patients with non-aborted lesions was 5.9 days.In a phase 3 trial in adults in which patients received a single 1500 mg dose of famciclovir or placebo, the median time to healing among patients with non-aborted lesions was 4.4 days in the famciclovir 1500 mg single-dose group and 6.2 days in the placebo group. You should continue to practice Do not take FAMVIR if you are allergic to any of its ingredients or to Before you start taking FAMVIR, tell your healthcare provider if you:Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Times to full lesion crusting and times to loss of Read this Patient Information before you start taking FAMVIR and each time you get a refill. %%EOF Although chickenpox and herpes zoster are caused by the same virus, the diseases are different.Clinical information on genital herpes in children is limited. Based on the pharmacokinetic data observed with these doses in children, a new weight-based dosing algorithm was designed and used in the multiple-dose safety part of the study. We comply with the HONcode standard for trustworthy health information - No famciclovir dosage adjustment based on gender is recommended.Famciclovir is a prodrug of penciclovir, which has demonstrated inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and In cell culture studies, penciclovir is inhibitory to the following herpes Penciclovir-resistant mutants of HSV and VZV can result from mutations in the viral thymidine kinase (TK) and DNA polymerase Cross-resistance has been observed among HSV DNA polymerase inhibitors. It may harm them.This leaflet summarizes the most important information about FAMVIR. If your sores have already formed a crust, do not take famciclovir as that’s a sign of sores healing.Associated symptoms such as fever, pain, and headaches may disappear within a few days after taking famciclovir, but cold sores usually take 2 to 4 weeks to heal completely.Carriers of HSV are always contagious. In addition, the efficacy cannot be extrapolated from adults to infants because there is no similar disease in adults. Applies to the following strengths: 125 mg; 250 mg; 500 mgRecurrent episodes of orolabial or genital herpes in HIV-infected patients: 500 mg orally twice a day for 7 days (5 to 10 days recommended by the CDC)Recurrent herpes labialis: 1500 mg orally as a single doseMild or moderate hepatic impairment: No adjustment recommended.Efficacy and safety have not been determined for initial genital herpes episodes, ophthalmic zoster, Black and African American patients with recurrent genital herpes, or immunocompromised patients other than for the treatment of recurrent orolabial or genital herpes in HIV-infected patients.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.