Pharyngitis or cough has been reported in 6-7.8 or 3.6-3.8%, respectively, of patients receiving the drug. US residents can call their local poison control center at 1-800-222-1222. Flonase (fluticasone) is a synthetic steroid of the glucocorticoid family of drugs and is prescribed for the control of symptoms of allergic and non-allergic rhinitis. An alternative 200-mcg/day dosage regimen can be given as 100 mcg twice daily (one 50-mcg spray in each nostril twice daily).Individual patients will experience a variable time to onset and different degree of symptom relief. The recommended starting dosage of Flonase in adults is 2 sprays (50 mcg of fluticasone propionate each) in each nostril once daily (total daily dose, 200 mcg). However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:This is not a complete list of possible side effects. When you prime the pump for the first time, press down and release the pump 6 times (Figure 2). In lactating rats, subcutaneous administration of tritiated fluticasone propionate (10 mcg/kg, approximately one-third the maximum recommended daily intranasal dosage in adults on a mcg/m basis) resulted in measurable radioactivity in both plasma and milk.The apparent elimination half-life of fluticasone propionate after IV administration is approximately 3 hours. Rhinitis is a word that means inflammation of the lining of the nose. The low bioavailability and small distribution of fluticasone propionate across the placenta may account for the lack of teratogenicity; in rats and rabbits receiving oral fluticasone propionate dosages of 100 mcg/kg (590 mcg/m) or 300 mcg/kg (3.6 mg/m), respectively, less than 0.008% of the dose crossed the placenta. From the primary population of 56 patients receiving Fluticasone Propionate Nasal Spray, USP and 52 receiving placebo, the point estimate for growth velocity with Fluticasone Propionate Nasal Spray, USP was 0.14 cm/year lower than that noted with placebo (95% confidence interval ranging from 0.54 cm/year lower than placebo to 0.27 cm/year higher than placebo). fluticasone propionate 50 mcg/actuation nasal spray,suspension. The commercially available preparation delivers about 120 metered sprays per 16-g bottle; the container should be discarded after the labeled number of actuations have been used since the correct dose per inhalation cannot be assured if used for additional doses. Therefore, coadministration of fluticasone propionate and ritonavir is not recommended unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side effects. These trials evaluated the total nasal symptom scores (TNSS) that included rhinorrhea, nasal obstruction, sneezing, and nasal itching in known allergic patients who were treated for 2 to 24 weeks. To do this:1. If you think you may have a serious medical problem, get medical help right away.Nasal dryness/irritation, nausea, or vomiting may occur. Loading... View More photos > ... Fluticasone is used to relieve seasonal and year-round allergic and non-allergic nasal symptoms, such as stuffy/runny nose, itching, and sneezing. Less than 2% of patients in clinical trials discontinued because of adverse events; this rate was similar for vehicle placebo and active comparators.Systemic corticosteroid side effects were not reported during controlled clinical studies up to 6 months’ duration with Fluticasone Propionate Nasal Spray, USP. However, the clinical significance of these findings in relation to the low plasma levels (see ) is not known. You may be directed to start with a higher dose of this drug for the first several days until you have begun to feel better, then decrease your dose. Rhinoscopic assessment or nasal examination of patients with rhinitis treated continuously with intranasal fluticasone propionate for 6-12 months has shown no evidence of serious mucosal damage.Adrenal suppression, based on mean plasma cortisol, morning plasma cortisol, or urinary 17-ketogenic steroid (17-KS) determinations, has Headache has been reported in 6.6-16.1% of patients receiving intranasal fluticasone propionate therapy (100-200 mcg once daily). Canada residents can call a provincial poison control center.If you use this medication for a long time, laboratory and/or medical tests (such as nose exams, height measurement in children) may be performed to monitor your progress and check for side effects.Avoid substances (such as pollen, pet dander, dust mites, mold, and smoke) that can worsen allergy symptoms.If you are using this product on a regular schedule and miss a dose, use it as soon as you remember.