DRESS typically, although not exclusively, presents with fever, rash, and/or lymphadenopathy, in association with other organ system involvement, such as hepatitis, nephritis, hematological abnormalities, myocarditis, or myositis sometimes resembling an acute viral infection. Response ratio was better in the Gabapentin 1,200 mg/day group (-0.103) than in the placebo group (-0.022); but this difference was also not statistically significant (p = 0.224). One of these reactions, a report of hostility, was considered serious. In these studies, either gabapentin or placebo was added to the patient's current antiepileptic drug therapy.Among the adverse reactions occurring at an incidence of at least 10% in gabapentin-treated patients, somnolence and ataxia appeared to exhibit a positive dose-response relationship.The overall incidence of adverse reactions and the types of adverse reactions seen were similar among men and women treated with gabapentin. In these trials, which had a median treatment duration of 12 weeks, the estimated incidence rate of suicidal behavior or ideation among 27,863 AED-treated patients was 0.43%, compared to 0.24% among 16,029 placebo-treated patients, representing an increase of approximately one case of suicidal thinking or behavior for every 530 patients treated. Check with your physician if you have any of the following: Conditions: suicidal thoughts; depression The types and incidence of adverse reactions were similar across age groups except for peripheral edema and ataxia, which tended to increase in incidence with age.Clinical studies of Gabapentin in epilepsy did not include sufficient numbers of subjects aged 65 and over to determine whether they responded differently from younger subjects. Patients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.Pooled analyses of 199 placebo-controlled clinical trials (mono- and adjunctive therapy) of 11 different AEDs showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo. The incidence of adverse reactions increased slightly with increasing age in patients treated with either Gabapentin or placebo. Of these, 14 patients had no prior history of status epilepticus either before treatment or while on other medications. Of these, 14 patients had no prior history of status epilepticus either before treatment or while on other medications. Driving performance studies conducted with a prodrug of gabapentin (gabapentin enacarbil tablet, extended release) indicate that gabapentin may cause significant driving impairment. These are not all the possible side effects of Gabapentin capsules. Patients should be instructed to discontinue Gabapentin and seek immediate medical care should they experience signs or symptoms of anaphylaxis or angioedema.Patients taking Gabapentin should not drive until they have gained sufficient experience to assess whether Gabapentin impairs their ability to drive. Responder rate was 23% (14/61) in the Gabapentin group and 9% (6/66) in the placebo group; the difference between groups was statistically significant. One of these reactions, a report of hostility, was considered serious. Other drugs with sedative properties may increase these symptoms. Gabapentin can be removed from plasma by hemodialysis.The effect of age was studied in subjects 20–80 years of age. Analyses were conducted using the ITT population (all randomized patients who received at least one dose of study medication).Both studies demonstrated efficacy compared to placebo at all doses tested.The reduction in weekly mean pain scores was seen by Week 1 in both studies, and were maintained to the end of treatment. Fatal respiratory depression has been reported with Gabapentin overdose, alone and in combination with other CNS depressants.If overexposure occurs, call your poison control center at 1-800-222-1222.The active ingredient in Gabapentin capsules, USP is Gabapentin, which has the chemical name 1-(aminomethyl) cyclohexaneacetic acid.Gabapentin is a white to off-white crystalline solid with a pKEach Gabapentin capsule, USP contains 100 mg, 300 mg, or 400 mg of Gabapentin and the following inactive ingredients: corn starch, lactose monohydrate, talc, D&C red 33 (300 mg only), D&C yellow 10 (300 mg only), gelatin, ferric oxide red (400 mg only), ferric oxide yellow (400 mg only), sodium lauryl sulfate, titanium dioxide, ferrosoferric oxide, potassium hydroxide, propylene glycol and shellac.The precise mechanisms by which Gabapentin produces its analgesic and antiepileptic actions are unknown. Looking across studies, a trend toward increasing efficacy with increasing age in patients with... 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