Yu R. Treatment of hyperthyroid disease. Reactions to skin tests may be suppressed.The dosage range for steroids is wide, and patient response is variable. Corticosteroids in terminal cancer: a prospective analysis of current practice. Therapeutic effects of steroids can often parallel undesirable side effects, especially when high doses and long-term therapy are required. Kairy SW, Action of oral methylprednisolone in terminal cancer patients: a prospective randomized double-blind study. Fenster LF. Imperiale TF, Dexamethasone is a long-acting, systemic corticosteroid; its potency is about 25 times greater than the short-acting products. Intraocular pressure should be checked frequently.The use of corticosteroids after cataract surgery may delay healing and increase the incidence of filtering blebs.Use of the ocular corticosteroids may prolong the course and may exacerbate the severity of many viral infections of the eye (including herpes simplex). Corticosteroids reduce the need for hospitalization in patients with croup and decrease morbidity and the incidence of respiratory failure in the treatment of patients with AIDS who havepneumonia. Franklyn JA. Khosla A, Pneumocystis pneumonia (PCP) is one of the most significant opportunistic infections that occurs in immunocompromised individuals. They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies.The use of a combination drug with an anti-infective component is indicated where the risk of infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye (see The particular anti-infective drugs in this product are active against the following common bacterial eye pathogens: The product does not provide adequate coverage against Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Ophthalmic Ointment is contraindicated in most viral diseases of the cornea and conjunctiva including: epithelial herpes simplex keratitis (dendritic keratitis), vaccinia and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures.Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Ophthalmic Ointment is also contraindicated in individuals who have shown hypersensitivity to any of its components. Randomized controlled trial of dexamethasone in tuberculous meningitis. Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Ophthalmic Ointment, USP is a sterile antimicrobial and anti-inflammatory ointment for ophthalmic use. Baugh R, Corticosteroid and croup. Employment of corticosteroid medication in the treatment of herpes simplex requires great caution; frequent slit lamp microscopy is recommended.Topical antibiotics, particularly neomycin sulfate, may cause cutaneous sensitization. Eden AN, Committee on Infectious Diseases 1994 Red book: report of the Committee on Infectious Diseases. Methylprednisolone as palliative therapy for female terminal cancer patients. Reactions to skin tests may be suppressed.Use with caution in patients at increased risk of developing osteoporosis; calcium supplements may be necessary, especially in postmenopausal women.Nausea/vomiting, weight loss/weight gain, abdominal distention, peptic ulcer, ulcerative esophagitis, pancreatitisThe risk of these effects increases with increased dosages and prolonged use; use of antiulcer agents is suggested only in patients requiring long-term steroid therapy at high dosages; use with caution or avoid in patients with GI diseases in which perforation or hemorrhage are potential risks.Hypercortisolism (Cushingoid state), secondary adrenal insufficiencyAssociated with long-term use even at lower dosagesMenstrual difficulties, including amenorrhea and postmenopausal bleedingIn patients with diabetes, increased dosages of insulin or oral hypoglycemic agent and changes in diet should be expected.Use with extreme caution in patients with recent myocardial infarction because of an apparent association with left ventricular free-wall rupture.Use with caution in patients with thromboembolic disorders because of reports of (rare) increased blood coagulability.Prolonged use may result in increased intraocular pressure or damaged ocular nerve.May enhance secondary fungal or viral infections of the eyeMuscle pain or weakness, muscle wasting, pathologic long bone or vertebral compression fractures, atrophy of protein matrix of bone, aseptic necrosis of femoral or humeral headsUse with caution in patients prone to development of osteoporosis; risk versus benefit should be reassessed if osteoporosis develops; elderly, debilitated or poorly nourished patients may be more prone to these effects.