This type of information is difficult to gather and to keep updated, because so many new drugs come out, and so many older drugs are pulled off the market. Severe Interactions. Summary: Drug interactions are reported among people who take Warfarin sodium and Hydroxyurea together. Drug Interactions between hydroxyurea and Vitamin D3. This is because vitamin K is a vitamin that contributes to blood clotting. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Our website services, content, and products are for informational purposes only. 1. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. If your body is metabolizing a medication too slowly, you may have more medication in your system at one time than intended — even if you’ve stuck to your normal dose. Before trying CBD, it’s crucial to talk to your doctor about all of the vitamins, supplements, and prescription and over-the-counter medications you’re taking. For example, increasing vitamin K levels in the body can promote clotting and reduce the effectiveness of warfarin. The study is based on hydroxyurea and warfarin sodium (the active ingredients of Hydroxyurea and Coumadin, respectively). Examples of these include broccoli and asparagus. However, even if you take one of these medications, your doctor might be able to formulate a plan that works for you through close monitoring of medication levels in your system. Healthline Media does not provide medical advice, diagnosis, or treatment. Summary: Drug interactions are reported among people who take Hydroxyurea and Coumadin together. In patients receiving long-term hydroxyurea for myeloproliferative disorders, secondary leukemia has been reported. Drug interactions are reported among people who take Hydroxyurea and Coumadin together. Hydroxyurea is used to treat chronic myeloid leukemia, ovarian cancer, and certain types of skin cancer (squamous cell cancer of the head and neck). Select one or more newsletters to continue. Hi R8ifg I have been on HU now for 18 months and also on warfarin. Advise protection from sun exposure and monitor for the development of secondary malignancies. eHealthMe has been monitoring drugs since 2008. If you want to try CBD as an add-on therapy to ease symptoms of a certain condition, talk to your doctor about it first. Hydroxyurea is also used to reduce pain episodes and the need for blood transfusions in people with sickle cell anemia. Although studies are still ongoing to determine potential interactions between CBD and specific medications, there’s one rule of thumb that can help consumers in the meantime: Avoid CBD if your medications have a This warning indicates that people taking the medication should avoid consuming grapefruit or grapefruit juice.Grapefruit warnings are common in several types of medications, but not all medications within a category will require the avoidance of grapefruit. Foods rich in vitamin K include beef liver, broccoli, Brussels sprouts, cabbage, collard greens, endive, kale, lettuce, mustard greens, parsley, soy beans, spinach, Swiss chard, turnip greens, watercress, and other green leafy vegetables. These vitamins can interfere with how Coumadin works. It can also lower the number of platelets, which are necessary for proper blood clotting. Drug metabolism happens throughout the body, such as in the gut, but the liver does a big part of the job, too. There have been reports of patients who experienced bleeding complications and increased INR or bleeding times after consuming large quantities of cranberry juice, mangos, grapefruit, grapefruit juice, grapefruit seed extract, or pomegranate juice. The study is created by eHealthMe based on reports of 106 people who take Warfarin sodium and Hydroxyurea from the Food and Drug Administration (FDA), and is updated regularly. This report displays the potential drug interactions for the following 2 drugs: hydroxyurea; Vitamin D3 (cholecalciferol) Edit list (add/remove drugs) Interactions between your drugs. That change in metabolism rate can alter how your body processes the medications or supplements you take — hence a drug interaction. Effects. Researchers are working to determine the specific interactions between CBD and various medications. Your doctor or pharmacist may also be able to recommend a quality CBD product that fits your needs. Don’t stop taking your prescription medications to try CBD, unless you have the go-ahead from your doctor.Medications that come with a grapefruit warning are likely to interact with CBD. Hydroxyurea will not cure sickle cell anemia. It is important to tell your doctor about all medications you use, including vitamins and herbs. However, even foods that do not contain much vitamin K may occasionally affect the action of warfarin. Acetaminophen, not to exceed 4 grams per day 3. We comply with the HONcode standard for trustworthy health information - That way, you can use both your prescription and CBD as a therapy. Don’t stop any of your medications to try CBD, unless your doctor says it’s safe to do so. Again, you do not need to avoid these foods completely, but it may be preferable to limit their consumption, or at least maintain the same level of use while you are receiving warfarin.