Side effects from excessive doses include weight loss, trouble tolerating heat, sweating, anxiety, trouble sleeping, Dosages vary according to the age groups and the individual condition of the person, body weight, and compliance to the medication and diet. However, if the serum TSH has not risen to greater than 20mU/L, levothyroxine treatment should be discontinued for another 30-day trial period followed by repeat serum TThe presence of concomitant medical conditions should be considered in certain clinical circumstances and, if present, appropriately treated (see The patient should be monitored closely to avoid undertreatment or overtreatment. LevothroidHypothyroidism during pregnancy is associated with a higher rate of complications, including spontaneous abortion, pre-eclampsia, stillbirth and premature delivery. Delays in diagnosis and institution of therapy may have deleterious effects on the child's intellectual and physical growth and development.Undertreatment and overtreatment should be avoided (see The recommended starting dose of levothyroxine sodium in newborn infants is Levothyroxine therapy is usually initiated at full replacement doses, with the recommended dose per body weight decreasing with age (see Hyperactivity in an older child can be minimized if the starting dose is one-fourth of the recommended full replacement dose, and the dose is then increased on a weekly basis by an amount equal to one-fourth the full-recommended replacement dose until the full recommended replacement dose is reached.Pregnancy may increase levothyroxine requirements (see If this condition is treated, a lower levothyroxine sodium dose (e.g., The target level for TSH suppression in these conditions has not been established with controlled studies. The choice of laboratory tests depends on various factors including the etiology of the underlying thyroid disease, the presence of concomitant medical conditions, including pregnancy, and the use of concomitant medications (see In adult patients with primary (thyroidal) hypothyroidism, serum TSH levels (using a sensitive assay) alone may be used to monitor therapy. It does get confusing. Thyroid hormone drug products formulated for intravenous administration should be administered.Store at 25°C (77°F) with excursions permitted to 15-30°C (59-86°F)The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. He just goes by the TSH readings. These consequences include, among others, effects on growth and development, cardiovascular function, bone metabolism, reproductive function, cognitive function, emotional state, gastrointestinal function, and on glucose and lipid metabolism. Too much thyroid hormone, whether it is created naturally in the body or given as a supplement in the form of levothyroxine, can cause weaker bones. The increased bone resorption may be associated with increased serum levels and urinary excretion of calcium and phosphorous, elevations in bone alkaline phosphatase and suppressed serum parathyroid hormone levels. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Hypersensitivity to levothyroxine itself is not known to occur.The signs and symptoms of overdosage are those of hyperthyroidism (see Levothyroxine sodium should be reduced in dose or temporarily discontinued if signs or symptoms of overdosage occur.This may be a life-threatening emergency, therefore, symptomatic and supportive therapy should be instituted immediately. Serum digitalis glycoside levels may be decreased when a hypothyroid patient becomes euthyroid, necessitating an increase in the dose of digitalis glycosides (see Consumption of certain foods may affect levothyroxine absorption thereby necessitating adjustments in dosing. Repeat thyroid function tests should be done five weeks after the dosage is increased. This can happen if you don’t test your Free T3 and Free T4 regularly and end up taking too much thyroid medication. Serum TSince some more severely affected children may become clinically hypothyroid when treatment is discontinued for 30 days, an alternate approach is to reduce the replacement dose of levothyroxine by half during the 30-day trial period.