Once punctured (in use), store vials refrigerated or at room temperature <30°C (<86°F) and use within 28 days. Our website services, content, and products are for informational purposes only. Insulin secretion and sensitivity may be partially or completely restored early after these procedures (gastric bypass is most effective, followed by sleeve and finally band) (Korner 2009; Peterli 2012). received honoraria from sanofi-aventis, MannKind, and Eli Lilly & Co. for scientific advising and consulting. Thus, in vivo, glargine does not exert its long-acting metabolic effects directly as glargine but predominantly via its main metabolite M1.While this article was in proof, an elegant in vitro study was published that showed that glargine displays higher potency than human insulin for stimulation of insulin/IGF-1 hybrid receptors with greater proliferative/antiapoptotic effects in MCF-7 cells. You should only use insulin glargine during pregnancy if the potential benefit justifies the potential risk.Insulin glargine injectable solution is used for long-term treatment. © 2005-2020 Healthline Media a Red Ventures Company. Some may be better suited for you than others. Using them together may increase your risk of water retention and heart problems, such as heart failure. Insulin glargine differs from human insulin in that the amino acid asparagine at position A21 is replaced by glycine and two arginines are added to the C-terminus of the B-chain. Females who are stable on insulin glargine prior to conception may continue it during pregnancy. Drug Interactions With Insulin Glargine: An Overview Insulin glargine (Lantus ®) can potentially interact with numerous other medicines, too many to list.Some insulin glargine drug interactions can result in dangerously low blood sugar levels (hypoglycemia). C.G.F. Submission of the dossier.....7 1.2. Evaluate risk versus benefit of long-term postoperative use, and consider alternative therapy due to potential for insulin-induced weight gain (Apovian 2015).• Cardiac disease: Concurrent use with peroxisome proliferator-activated receptor (PPAR)-gamma agonists, including thiazolidinediones, may cause dose-related fluid retention and lead to or exacerbate heart failure (HF), particularly when used in combination with insulin. This may raise your risk of high blood sugar. Monitor patients for fluid retention and signs/symptoms of heart failure, and consider pioglitazone dose reduction or discontinuation if heart failure occursPramlintide: May enhance the hypoglycemic effect of Insulins. This may raise your risk of high blood sugar. Do not share your pen device with another person, even if the needle is changed. Your dose, form, and how often you use it will depend on:This drug hasn’t been established as safe and effective for use in children younger than 6 years for the treatment of type 1 diabetes.This drug hasn’t been established as safe and effective for use in children younger than 18 years.This drug hasn’t been established as safe and effective for use in children younger than 18 years who have type 2 diabetes.This drug hasn’t been established as safe and effective in people younger than 18 years who have type 2 diabetes. This medication may be available under multiple brand names and/or in several different forms. Dosage requirements may be reduced.• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Insulin glargine may be administered as a single daily dose (manufacturer's labeling); in some cases, administration of U-100 (100 units/mL) insulin glargine formulations as 2 divided doses may be beneficial (Ashwell 2006; Youssef 2010).Prandial insulin: The remaining portion (ie, 50% to 60%) of the TDD is then divided and administered before, at, or just after mealtimes, depending on the formulation (eg, short-, rapid-, ultra-rapid-acting) (AACE/ACE [Handelsman 2015]; ADA 2020).Converting from once-daily NPH insulin to insulin glargine: May be substituted on an equivalent unit-per-unit basis.Converting from twice-daily NPH insulin to insulin glargine: Initial dose: Use 80% of the total daily dose of NPH (eg, 20% reduction); administer once daily; adjust dosage according to patient response.Converting from once-daily insulin detemir to Toujeo: May be substituted on an equivalent unit-per-unit basis.Converting from twice-daily insulin detemir to Toujeo: Initial dose: Use 80% of the total daily dose of insulin detemir (eg, 20% reduction); administer once daily; adjust dosage according to patient response.Conversion from once-daily Toujeo (300 units/mL) to once-daily Lantus, Basaglar, or Semglee (100 units/mL): Initial dose: Use 80% of the dose of Toujeo (eg, 20% reduction); adjust dosage according to patient blood glucose response.Conversion from once-daily Lantus to once-daily Toujeo or once-daily Basaglar: Initial dose: May be substituted on an equivalent unit-per-unit basis; however, generally a higher daily dosage of Toujeo will be required to achieve the same level of glycemic control as with Lantus.Insulin glargine is a long-acting insulin. 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