Ivermectin is a medication used to treat many types of parasite infestations. The amount absorbed follows a linear dose-relationship, as C max and AUC increase proportionally with dose (Daurio et al., 1992). Ivermectin is also used to control onchocerciasis (river blindness; infection with a type of roundworm that may cause rash, bumps under the skin, and vision problems including vision loss or blindness). Ivermectin is an anti-parasite medication with activity against several parasitic nematodes (parasitic worms) and scabies and is the treatment of choice for onchocerciasis (also called “river blindness” because the blood-feeding flies that transmit the ultimately blinding disease inhabit lush, fertile land alongside the rivers in which they breed). The kinetics of ivermectin are characterised, in general terms, by a slow absorption process, a broad distribution in the organism, low metabolism, and slow excretion. Retreatment is required because ivermectin has no activity against adult onchocerca volvulus parasites which tend to reside in subcutaneous nodules. Each ivermectin dose should be taken on an empty stomach with a full (8 oz) glass of water. Common or very common. General side-effects. This includes head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis, and lymphatic filariasis. Use in the eyes should be avoided. We comply with the HONcode standard for trustworthy health information - It treats strongyloidosis by killing the worms in the intestines. Characterisation of ivermectin kinetics can be used to predict and optimise the value of the parasiticide effects and to design programmes for parasite control. Select one or more newsletters to continue. Interactions. Oral bioavailability is greater if the tablets are chewable. Allergic and inflammatory reactions (the Mazzotti reaction) may occur with ivermectin, probably due to the death of the microfilariae. A recent pharmacokinetics study reports that following a high-fat meal absorption was significantly higher (about 2.5 times) than in the fasted state. Route-specific information. Ivermectin is unlicensed. Absorption of ivermectin is faster in dogs than in ruminants and pigs, and similar to horses. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. See below for a comprehensive list of adverse effects. Common side effects include red eyes, dry skin, and burning skin. ScienceDirect ® is a registered trademark of Elsevier B.V.The pharmacokinetics and metabolism of ivermectin in domestic animal speciesCopyright © 2007 Elsevier Ltd. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. Patients treated with ivermectin therapy for onchocerciasis may experience these reactions in addition to clinical adverse reactions possibly, probably, or definitely related to the therapy itself. It can be taken by mouth or applied to the skin for external infestations. Commonly reported side effects of ivermectin include: fever, pruritus, and skin rash. Individual interactants: Ivermectin ; Side-effects. Ivermektin, někdy nazývaný také invermektin, je širokospektrální antiparazitikum používané v humánní i veterinární medicíně proti parazitickým hlísticím a některým ektoparazitům jako jsou vši, střečci či zákožky.Z chemického hlediska patří mezi makrocyklické laktony. The kinetics vary according to the route of administration, formulation, animal species, body condition, age, and physiological status, all of which contribute to differences in drug efficacy. Surgical excision of these nodules may be considered to eliminate the adult reproduction of microfilariae.Cutaneous, systemic and/or ophthalmological reactions have been reported with other microfilaricidal drugs. Skin reactions. The treatment of severe Mazzotti reactions has not been subjected to controlled clinical studies. semisynthetic deworming and anti-inflammatory drug derived from avermectin – a bacterial macrocyclic lactone