Labetalol was given by incremental intravenous infusion to nineteen severely hypertensive patients, of whom nine were refractory to previous oral antihypertensive therapy. Labetalol for hypertensive urgency. Intravenous labetalol appears effective and well tolerated in the control of blood pressure in hypertensive emergencies. doi: 10.1016/j.ajog.2020.02.009. If the systolic BP is above 220 mmHg or the diastolic BP is between 121-140 mmHg, labetalol can be used to achieve a 10% to 15% reduction in BP within 24 hours. Labetalol (Trandate; Alien & Hanburys), an a-and tl-adreno ceptor blocking agent, has emerged in recent years as a possible alternative in the management of acute hypertensive Please enable it to take advantage of the complete set of features! Divisions of Nephrology and Research, L'Hôtel‐Dieu de Québec and Department of Medicine, Laval UniversityDivisions of Nephrology and Research, L'Hôtel‐Dieu de Québec and Department of Medicine, Laval UniversityDivisions of Nephrology and Research, L'Hôtel‐Dieu de Québec and Department of Medicine, Laval UniversityDivisions of Nephrology and Research, L'Hôtel‐Dieu de Québec and Department of Medicine, Laval UniversityDivisions of Nephrology and Research, L'Hôtel‐Dieu de Québec and Department of Medicine, Laval UniversityDivisions of Nephrology and Research, L'Hôtel‐Dieu de Québec and Department of Medicine, Laval UniversityDivisions of Nephrology and Research, L'Hôtel‐Dieu de Québec and Department of Medicine, Laval UniversityDivisions of Nephrology and Research, L'Hôtel‐Dieu de Québec and Department of Medicine, Laval UniversityUse the link below to share a full-text version of this article with your friends and colleagues. 2013 Aug;37(4):280-7. doi: 10.1053/j.semperi.2013.04.007.Am J Obstet Gynecol. 2. Clipboard, Search History, and several other advanced features are temporarily unavailable. Labetalol is a combined. Smooth reduction of arterial pressure was achieved in twelve subjects; one remained resistant to labetalol up to 160 mg/h; a sudden fall in pressure occurred in the remaining six. Kantorowska A, Heiselman CJ, Halpern TA, Akerman MB, Elsayad A, Muscat JC, Sicuranza GB, Vintzileos AM, Heo HJ.Am J Obstet Gynecol. Kaplan's clinical hypertension, 9th ed. Register 1999 Oct;181(4):858-61. doi: 10.1016/s0002-9378(99)70314-5.Clin Obstet Gynecol. Kaplan NM. Name must be less than 100 characters By continuing to browse this site, you agree to its use of cookies as described in our I have read and accept the Wiley Online Library Terms and Conditions of Use© 2020 American Society for Clinical Pharmacology and Therapeutics This site needs JavaScript to work properly. 1995 Aug;35(8):747-62. doi: 10.1002/j.1552-4604.1995.tb04116.x.Semin Perinatol. Oral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for … Intravenous labetalol appears effective and well tolerated in the control of blood pressure in hypertensive emergencies.Please check your email for instructions on resetting your password. The antihypertensive effects of labetalol infusion (2 mg/min; maximal dose 150 mg) were evaluated in 22 subjects requiring rapid lowering of blood pressure because of severe hypertension, a hypertensive crisis after surgery, or before angiographic examination. By the end of the infusion, diastolic blood pressure in 16 (73%) subjects was lowered to ≤110 mm Hg. Hypertensive urgencyasymptomatic severe hypertension. Recent findings: New literature and recommendations for managing hypertensive emergencies in the setting of pregnancy, stroke, and heart failure have been published. Vaughan CJ, Delanty N. Hypertensive emergencies. 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