doi: 10.1016/j.clbc.2017.11.006. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. 2003 Apr;4 Suppl 1:S42-8. These side effects may go away during treatment as your body adjusts to the medicine. Epub 2015 Dec 11.Jenkins VA, Ambroisine LM, Atkins L, Cuzick J, Howell A, Fallowfield LJ.Lancet Oncol. Letrozole rarely causes vaginal bleeding. Weight gain. Data on weight change in postmenopausal women from three large clinical trials investigating endocrine therapy for the treatment or prevention of breast cancer were analysed (ATAC, IBIS-I and IBIS-II). Dr. Quang Nguyen answered. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. But, An unfortunate fact remains. Epub 2015 Dec 11.Margolese RG, Cecchini RS, Julian TB, Ganz PA, Costantino JP, Vallow LA, Albain KS, Whitworth PW, Cianfrocca ME, Brufsky AM, Gross HM, Soori GS, Hopkins JO, Fehrenbacher L, Sturtz K, Wozniak TF, Seay TE, Mamounas EP, Wolmark N.Lancet. 2018 Feb;18(1):e7-e13. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). For a long time my weight was steady but over the last few weeks I have actually been losing weight despite no changes in my eating habits. I'm not sure where you got the information that fewer pt.s survived while being treated with Femara than those taking Tamoxifen. In the ATAC trial, no statistically significant differences in weight gain between anastrozole and tamoxifen were found after 12 months of follow-up [+1.4 kg (SD 3.9) vs. +1.5 kg (SD 4.0), P = 0.4]. Springer Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Along with its needed effects, a medicine may cause some unwanted effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Other side effects not listed may also occur in some patients. Name must be less than 100 characters 2016 Feb 27;387(10021):849-56. doi: 10.1016/S0140-6736(15)01168-X. In fact, according to an article published in the World Journal of Clinical Oncology, you can expect to gain anywhere from 2 to 11 pounds. Many women gain weight during breast cancer treatment. 2016 Feb 27;387(10021):866-73. doi: 10.1016/S0140-6736(15)01129-0. Femara is used for pt.s who are being treated for metastatic breast cancer and this would be the reason for the decreased survival rate ... not the Femara itself. 2018 Dec 1;124(23):4512-4519. doi: 10.1002/cncr.31775. Eating healthily and being physically active can help to keep you to a healthy weight: however, it is difficult to be physically acive when you also have the side effects of tiredness or joint and muscle pain. Since weight gain may impact on outcome and compliance we have prospectively assessed the effects of these agents on weight change in three randomised trials for the treatment or prevention of breast cancer. With the shock of diagnosis, the … Please enable it to take advantage of the complete set of features! 2017 Nov 9;377(19):1836-1846. doi: 10.1056/NEJMoa1701830.Simigdala N, Gao Q, Pancholi S, Roberg-Larsen H, Zvelebil M, Ribas R, Folkerd E, Thompson A, Bhamra A, Dowsett M, Martin LA.Breast Cancer Res. Unable to load your delegates due to an error Hi again, I’m here to talk about Letrozole again- but this time in the context of weight gain. Weight gain is a potential side effect of tamoxifen. Weight gain is commonly reported by breast cancer patients on tamoxifen or aromatase inhibitors. Springer Weight gain is commonly reported by breast cancer patients on tamoxifen or aromatase inhibitors. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Some side effects may occur that usually do not need medical attention. How many of you ladies have gained weight from taking it? All rights reserved. 84% Upvoted. You may put on weight when you’re taking hormonal therapy. I noticed I was overly bloated recently so I looked this up and it seems like weight gain is a side effect. This site needs JavaScript to work properly. Unable to load your collection due to an error Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.