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Patients with renal insufficiency had a higher prevalence of diabetes mellitus compared with those with normal renal function (64.7% vs. 22.2%; We use cookies to help provide and enhance our service and tailor content and ads.
By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine
A Possible Case of Vertical Transmission of SARS-CoV-2 in a Newborn with Positive Placental In Situ Hybridization of SARS-CoV-2 RNA
Close monitoring of renal function should be considered during LZD therapy. Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic reviewLinezolid for the treatment of children with bacteremia or nosocomial pneumonia caused by resistant gram-positive bacterial pathogensLinezolid for the treatment of complicated skin and skin structure infections in childrenClinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterialHigh plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopeniaHigh frequency of linezolid associated thrombocytopenia among patients with renal insufficiencyHigh frequency of linezolid-associated thrombocytopenia and anemia among patients with end-stage renal diseaseHigher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunctionInfluence of linezolid clearance on the induction of thrombocytopenia and reduction of hemoglobinCorrelation between serum linezolid concentration and the development of thrombocytopenia
CONCLUSIONS: This study indicates that LALA occurs more frequently than VALA does and is associated with renal insufficiency. ScienceDirect ® is a registered trademark of Elsevier B.V.High frequency of linezolid-associated thrombocytopenia among patients with renal insufficiencyCopyright © 2006 Elsevier B.V. and the International Society of Chemotherapy. Additional studies are needed to determine whether dose modifications are warranted for children receiving LZD with renal impairment.All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.Drugs and Other Factors Contributing to Thrombocytopenia S. J. J. and H. L. D. were PharmD candidates at Butler University College of Pharmacy and Health Sciences at time of research completion.Oxford University Press is a department of the University of Oxford. The method of data collection and reporting did not allow for consideration of CrCl changes or dose changes over the course of therapy. TDM is a very useful tool for patient populations with sparse clinical data or known alterations in pharmacokinetics, including children, patients with renal insufficiency or those receiving renal replacement therapy, and patients taking co-medications known to interact with linezolid. Creatinine clearance was calculated based upon date of initial LZD dose, and 2 different methods for CrCl estimation were used, but it is not expected that the different equations would significantly alter our findings. In addition, it is not possible to determine whether further decreases in platelet values could be attributable to LZD, as opposed to underlying condition, in those patients who had a low baseline platelet value before starting LZD.In addition, platelet values could be elevated during infection and subsequently lowered with the course of treatment and should not necessarily be considered a linezolid-associated adverse effect. The study was limited to patients less than 18 years of age who had retrievable serum creatinine and height values. Findings from this retrospective cohort demonstrate an association between thrombocytopenia and lower creatinine clearance in children receiving linezolid. Incidence is wide ranging in adults with a higher incidence of 31%–66% in adults with renal impairment [ This was a retrospective, single-center cohort study. Eligible patients were identified using a pharmacy computer system-generated report of patients who received LZD therapy between January 1, 2007 and March 31, 2012. Medical records were reviewed for demographics, LZD utilization, and clinical and laboratory parameters (including, but not limited to serum creatinine, platelet values, indication, and concomitant vancomycin). J. J. and H. L. D. were PharmD candidates at Butler University College of Pharmacy and Health Sciences at time of research completion.Sara J. Jones, Kristen R. Nichols, Heather L. DeYoung, Elaine G. Cox, Chad A. Knoderer, Linezolid-Associated Thrombocytopenia in Children With Renal Impairment, Impaired renal function has been associated with an increased risk of thrombocytopenia in adults receiving linezolid. Material and methods The case report was in relation to severe thrombocytopenia (platelet count <100 × 109 platelets/L) in a patient with haemodialysis who was treated with linezolid for VRE infection. Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine
The effect of renal insufficiency on erythrocyte and platelet counts in patients undergoing linezolid treatment has still not been elucidated. Children had a median (IQR) baseline CrCl (ml per min per 1.73 m Thrombocytopenia was evaluable in 162 (95%) patients and occurred in 48 (29%).