In such circumstances, no dose adjustment is required as linezolid has an oral bioavailability of approximately 100%.The duration of treatment is dependent on the pathogen, the site of infection and its severity, and on the patient's clinical response.The following recommendations for duration of therapy reflect those used in the clinical trials. However, because the mean half-life of linezolid is not significantly different in males and females, plasma concentrations in females are not expected to substantially rise above those known to be well tolerated and, therefore, dose adjustments are not required.Linezolid decreased fertility and reproductive performance of male rats at exposure levels approximately equal to those expected in humans. Do not use two doses at one time.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.pickled or fermented meats, smoked or air-dried meats;any meat, cheese, or other protein-based food that has been improperly stored.You should be very familiar with the list of foods you must avoid while you are using linezolid.severe stomach pain, diarrhea that is watery or bloody;sweating, feeling anxious or shaky (may be signs of low blood cell counts--fever, chills, tiredness, weakness, confusion, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, This is not a complete list of side effects and others may occur. Due to the unknown clinical significance of higher exposure (up to 10-fold) to the two primary metabolites of linezolid in patients with severe renal insufficiency, linezolid should be used with special caution in these patients and only when the anticipated benefit is considered to outweigh the theoretical risk.As approximately 30% of a linezolid dose is removed during 3 hours of haemodialysis, linezolid should be given after dialysis in patients receiving such treatment. In vitro studies with clinical isolates (including methicillin-resistant staphylococci, vancomycin-resistant enterococci, and penicillin- and erythromycin-resistant streptococci) indicate that linezolid is usually active against organisms which are resistant to one or more other classes of antimicrobial agents.Resistance to linezolid is associated with point mutations in the 23S rRNA.As documented with other antibiotics when used in patients with difficult to treat infections and/or for prolonged periods, emergent decreases in susceptibility have been observed with linezolid. Resistance to linezolid has been reported in enterococci, In an open study, the efficacy of linezolid (10 mg/kg q8h) was compared to vancomycin (10-15mg/kg q6-24h) in treating infections due to suspected or proven resistant Gram-positive pathogens(including nosocomial pneumonia, complicated skin and skin structure infections, catheter related bacteraemia, bacteraemia of unknown source, and other infections), in children from birth to 11 years. However, as linezolid is metabolised by a non-enzymatic process, impairment of hepatic function would not be expected to significantly alter its metabolism (see sections 4.2 and 4.4).There are insufficient data on the safety and efficacy of linezolid in children and adolescents (< 18 years old) and therefore, use of linezolid in this age group is not recommended (see section 4.2). 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