Fored CM, Gill J, Singh H, Nugent K. Acute lithium intoxication and neuroleptic malignant syndrome. 2010;71(9):1153–7.Selim G, Stojceva-Taneva O, Spasovski G, Tozija L, Grozdanovski R, Georgievska-Ismail L, et al. Kellum JA, Guo X, Treatment-related acute renal failure in the elderly: a hospital-based prospective study. For information about the SORT evidence rating system, go to GFR = glomerular filtration rate; MDRD = Modification of Diet in Renal DiseaseA = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Lithium-induced nephrogenic diabetes insipidus is usually self-limiting or not clinically … Clipboard, Search History, and several other advanced features are temporarily unavailable. Toxic acute tubular necrosis following treatment with zoledronate (Zometa). Markowitz GS, Gen Hosp Psychiatry. Herbs and the kidney. Lancet. Wong A, Webster AC, Community-acquired acute renal failure. Tubulointerstitial diseases: drug-induced chronic interstitial nephritis. An exception to this is an increase in serum creatinine following the initiation of cimetidine (Tagamet) or tri-methoprim (Proloprim), because they compete with creatinine for tubular secretion and are not associated with kidney damage or urine abnormalities.At the first sign of renal dysfunction, the patient's medication list should be reviewed to identify offending agents. There was no internal or external funding provided for the production of this manuscript.All data generated and/or analysed during the current study are contained within an endnote user file, and are available from the corresponding author upon reasonable request.Department of Renal Medicine, University Hospital Geelong, Rotary House, 325 Ryrie St, Geelong, VIC, AustraliaIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, 75 Pigdons Road, Geelong, AustraliaOrygen, The National Centre of Excellence in Youth Mental Health, the Department of Psychiatry, and the Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, AustraliaYou can also search for this author in Whelton PK, Search Stack JI, Hix JK, Long-term, low-dose lithium treatment does not impair renal function in the elderly: a 2-year randomized, placebo-controlled trial followed by single-blind extension. 2016;19(4):e22.Close H, Reilly J, Mason JM, Kripalani M, Wilson D, Main J, et al. 1997 Feb;42(1):16-7. doi: 10.1177/003693309704200106.Beunders AJM, Hillegers MHJ, Regeer EJ, Vervloet MG, Gaillard CAJM, Dols A.J Med Toxicol. Despite lithium being the most efficacious treatment for bipolar disorder, its use has been decreasing at least in part due to concerns about its potential to cause significant nephrotoxicity. Despite these differences, the weight of evidence suggests that lithium has the potential to cause end stage kidney disease, albeit over a prolonged period.A search strategy for this review was developed to identify appropriate studies, sourced from the electronic databases EMBASE, PubMed (NLM) and MEDLINE. Int J Geriatr Psychiatry. Risk factors for acute renal failure: inherent and modifiable risks. Whilst the ability of lithium This difficulty is further compounded by the need of people suffering from bipolar disorder to take chronic therapy in order to prevent their risk of relapse. Renal Insufficiency Following Contrast Media Administration Trial (REMEDIAL): a randomized comparison of 3 preventive strategies. Bellomo R. Drug-induced acute interstitial nephritis. Renal replacement therapy associated with lithium nephrotoxicity in New Zealand. 1, 2 Despite the therapeutic advantages, the use of lithium has been decreasing at least in part because of the perceived risks surrounding its use, including the potential for nephrotoxicity with long term use. Cochrane Database Syst Rev. Klasner AE. Some patient-related risk factors for drug-induced nephrotoxicity are age older than 60 years, underlying renal insufficiency (e.g., glomerular filtration rate of less than 60 mL per minute per 1.73 mDrugs cause approximately 20 percent of community-and hospital-acquired episodes of acute renal failure.Patients at highest risk of drug-induced nephrotoxicity are those with one or more of the following: age older than 60 years, baseline renal insufficiency (e.g., GFR < 60 mL per minute per 1.73 mAssess baseline renal function using the MDRD or Cockcroft-Gault GFR estimation equation and consider a patient's renal function when prescribing a new drug.Monitor renal function and vital signs after starting or increasing the dose of drugs associated with nephrotoxicity, especially when used chronically.Drug-induced renal impairment is generally reversible, provided the nephrotoxicity is recognized early and the offending medication is discontinued.Patients at highest risk of drug-induced nephrotoxicity are those with one or more of the following: age older than 60 years, baseline renal insufficiency (e.g., GFR < 60 mL per minute per 1.73 mAssess baseline renal function using the MDRD or Cockcroft-Gault GFR estimation equation and consider a patient's renal function when prescribing a new drug.Monitor renal function and vital signs after starting or increasing the dose of drugs associated with nephrotoxicity, especially when used chronically.Drug-induced renal impairment is generally reversible, provided the nephrotoxicity is recognized early and the offending medication is discontinued.Most drugs found to cause nephrotoxicity exert toxic effects by one or more common pathogenic mechanisms.