All rights reserved. If you develop increased thirst, urination or hunger, blurry vision, headaches or your breath smells like fruit, notify your healthcare team. The solubility of lorlatinib in aqueous media decreases over the range pH 2.55 to pH 8.02 from 32.38 mg/mL to 0.17 mg/mL. Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Do not take two doses at the same time to make up for a missed dose. Lorlatinib comes as a tablet to take by mouth.
Patients receive lorlatinib orally (PO) once daily (QD) on days 1-21. Check with your doctor right away if you have new or worsening cough, fever, or trouble breathing. The CNS is a term used to refer to the brain and spinal cord, including the lining of the brain and spinal cord which is called the meninges. These are life-threatening conditions and require immediate medical attention. Lorlatinib is a white to off-white powder with a pKa of 4.92. Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … in your body. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Portions of this document last updated: Sept. 01, 2020Copyright © 2020 IBM Watson Health. Lorlatinib can make hormonal methods of birth control ineffective. Your care team can help you find these resources, if they are available.There are a number of things you can do to manage the side effects of lorlatinib. They can help you decide what will work best for you. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. The symptoms may be similar to the symptoms of lung cancer.
In some cancers, this receptor is overactive, causing cells to grow and divide too fast. The symptoms may be similar to the symptoms of lung cancer. This medication may be covered under your prescription drug plan. While receiving treatment, your This medication can affect the normal levels of electrolytes (potassium, magnesium, phosphorus, etc.) You might feel dizzy or faint, or you might have a slow, fast, pounding, or uneven heartbeat. These could be symptoms of a serious liver problem. Your oncology team will test your tumor for this abnormality, which must be present in order to receive the medication.Lorlatinib is taken by mouth, in tablet form.
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It is usually taken with or without food once daily. Jetzt kostenlos registrieren. Notify your provider if you are experiencing any new or worsening swelling.Lorlatinib can increase the cholesterol and triglyceride (lipid) levels in your blood. Patient assistance may be available to qualifying individuals depending upon prescription drug coverage. Your levels will be monitored using blood tests. All content © 2020 Trustees of the University of Pennsylvania.
Be sure to tell your healthcare provider about all medications and supplements you take.Store your medication in the original, labeled container at room temperature and in a dry location (unless otherwise directed by your healthcare provider or Pharmacist). In this phase 1, dose-escalation study, lorlatinib showed both systemic and intracranial activity in patients with advanced ALK-positive or ROS1-positive NSCLC, most of whom had CNS metastases and had previously had two or more TKI treatments fail. Lorlatinib has been tested in other research studies and results show that the medicine may help to control the growth of NSCLC even after it has spread to the CNS. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Talk to your care team about these recommendations. Skip the dose if it is less than 4 hours before the next dose. The swelling can become uncomfortable. This medication should not be stored in a pillbox. If you think you have become pregnant while using this medicine, tell your doctor right away.