Because the study was designed to achieve equal blood pressure control in both groups, other antihypertensive agents (diuretics, calcium-channel blockers, alpha- or beta-blockers, and centrally acting agents) could be added as needed in both groups. Patients with myocardial infarction or stroke within six months prior to randomization were excluded. In nonpregnant rats dosed at 135 mg/kg/day for 7 days, systemic exposure (AUCs) for Losartan and its active metabolite were approximately 66 and 26 times the exposure achieved in man at the maximum recommended human daily dosage (100 mg).The antihypertensive effects of Losartan potassium were demonstrated principally in 4 placebo-controlled, 6- to 12 week trials of dosages from 10 to 150 mg per day in patients with baseline diastolic blood pressures of 95 to 115. The mean length of follow-up was 4.8 years. Medizzine le recomienda que consulte a su medico si desconoce la razón por la que le ha prescrito losartán.Ademas del principio activo losartán, las presentaciones comerciales llevan celulosa microcristalina, lactosa hidratada, almidón de maÃz pregelatinizado,
La dosis puede aumentarse hasta 100 mg una vez al dÃa.La dosis inicial es de 12,5 mg una vez al dÃa, aunque esta dosis puede aumentarse hasta
The primary endpoint was the first occurrence of stroke, myocardial infarction or cardiovascular death, analyzed using an intention-to-treat (ITT) approach. The purpose of this study is to see whether a high dose of losartan (200 mg) has a greater effect on the sympathetic nervous system than a low dose of losartan (50 mg) does. Monitor serum potassium in such patients.Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists. Patients with nonfatal events remained in the trial, so that there was also an examination of the first event of each type even if it was not the first event (e.g., a stroke following an initial myocardial infarction would be counted in the analysis of stroke). When pregnancy is detected, discontinue Losartan as soon as possible. Monitor serum lithium levels during concomitant use.In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists (including Losartan) may result in deterioration of renal function, including possible acute renal failure. Patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury. Patients receiving the combination of Losartan and lisinopril did not obtain any additional benefit compared to monotherapy for the combined endpoint of decline in GFR, end stage renal disease, or death, but experienced an increased incidence of hyperkalemia and acute kidney injury compared with the monotherapy group.In most patients no benefit has been associated with using two RAS inhibitors concomitantly. However, the LIFE study provides no evidence that the benefits of Losartan potassium on reducing the risk of cardiovascular events in hypertensive patients with left ventricular hypertrophy apply to Black patients Patients with renal insufficiency have elevated plasma concentrations of Losartan and its active metabolite compared to subjects with normal renal function. Overall, 72% of patients received the 100-mg daily dose more than 50% of the time they were on study drug. Keep container tightly closed. Losartan potassium tablets are indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older, to lower blood pressure. Select one or more newsletters to continue. In long-term follow-up studies (without placebo control) the effect of Losartan appeared to be maintained for up to a year. 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