Lamotrigine oral tablet is a prescription medication used to treat seizures in people with epilepsy and bipolar disorder. It may take several weeks to months to achieve an individualized maintenance dose. There are suggestions, yet to be proven, that the risk of severe, potentially life-threatening rash may be increased by (1) coadministration of LAMICTAL with valproate, (2) exceeding the recommended initial dose of LAMICTAL, or (3) exceeding the recommended dose escalation for LAMICTAL. by 50 mg/day q1-2wk; Max: 375 mg/day; Info: dose adjustment may be needed during pregnancy and/or postpartum; taper dose over 2wk to D/C seizures, Lennox-Gastaut syndrome [valproate adjunct] If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. If a patient has discontinued lamotrigine for a period of more than 5 half-lives, it is recommended that initial dosing recommendations and guidelines be followed. In one study, Lamictal was given as an add-on medicine for patients with the pattern of seizures called Lennox-Gastaut syndrome. Dose escalation should follow the recommended guidelines for initiating adjunctive therapy with LAMICTAL based on concomitant AED or other concomitant medications (see Tables Experience in patients with hepatic impairment is limited. Dosage Adjustments to LAMICTAL in Adults with Bipolar Disorder following Discontinuation of Psychotropic MedicationsDiscontinuation of Psychotropic Drugs (excluding Valproate,After Discontinuation of Carbamazepine, Phenytoin, Phenobarbital, or PrimidoneNo attempt should be made to administer partial quantities of the dispersed tablets.We comply with the HONcode standard for trustworthy health information - If the decision is made to restart a patient who has discontinued LAMICTAL, the need to restart with the initial dosing recommendations should be assessed. Available for Android and iOS devices. Escalation Regimen for LAMICTAL in Patients Older than 12 Years with EpilepsyIn Patients NOT TAKING Carbamazepine, Phenytoin, Phenobarbital, Primidone,In Patients TAKING Carbamazepine, Phenytoin, Phenobarbital, or Primidone100 to 400 mg/day with valproate and other drugs that induce glucuronidationTable 2. Maintenance doses in patients weighing <30 kg, regardless of age or concomitant AED, may need to be increased as much as 50%, based on clinical response.The smallest available strength of LAMICTAL tablets for oral suspension is 2 mg, and only whole tablets should be administered. Lamictal is used to treat several different types of seizures. Drugs that induce glucuronidation include carbamazepine, phenytoin, phenobarbital, primidone, rifampin, estrogen-containing oral contraceptives, and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir. Follow your doctor's orders or the directions on the label. The Initial Weight-Based Dosing Guide for Patients Aged 2 to 12 Years Taking Valproate (Weeks 1 to 4) with EpilepsyGive this daily dose, using the most appropriate combination of LAMICTAL 2- and 5-mg tabletsConversion from Adjunctive Therapy with Carbamazepine, Phenytoin, Phenobarbital, or Primidone to Monotherapy with LAMICTALConversion from Adjunctive Therapy with Valproate to Monotherapy with LAMICTALTable 4. Dosing of LAMICTAL should be based on therapeutic response The effect of other hormonal contraceptive preparations or hormone replacement therapy on the pharmacokinetics of lamotrigine has not been systematically evaluated. The dose of this medicine will be different for different patients. However, cases have occurred in the absence of these factors [see Boxed Warning]. In particular, the introduction of valproate requires reduction in the dose of LAMICTAL To avoid an increased risk of rash, the recommended initial dose and subsequent dose escalations of LAMICTAL should not be exceeded LAMICTAL tablets for oral suspension may be swallowed whole, chewed, or dispersed in water or diluted fruit juice. Escalation Regimen for LAMICTAL in Patients Aged 2 to 12 Years with EpilepsyNote: Only whole tablets should be used for dosing.In Patients NOT TAKING Carbamazepine, Phenytoin, Phenobarbital, Primidone,In Patients TAKING Carbamazepine, Phenytoin, Phenobarbital, or PrimidoneTable 3.