Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor.
These effects may contribute to its anti-inflammatory activityPeak Plasma Time: 2-4 hr (1 g dose); reached by the second day of administration (1 g dose, 4x daily)Peak Plasma Concentration: 10 mcg/mL (1 g dose); 20 mcg/mL (1 g dose, 4x daily)Metabolites: 3'-hydroxymethyl and 3'-carboxyl acid metabolites and their glucuronic acid conjugatesAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans.
Thus, mefenamic acid reduces the synthesis of prostaglandins. 2018 Jan 17;15(1):21. doi: 10.1186/s12974-018-1054-3.Guo JY, Li CY, Ruan YP, Sun M, Qi XL, Zhao BS, Luo F.Eur J Pharmacol. Published by Elsevier B.V. Practice Guideline
(CMAJ, September 6, 2011; DOI:10.1503/cmaj.110454)Lactation: contraindicated; excreted in breast milkA: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2)May inhibit chemotaxis, may alter lymphocyte activity, decrease proinflammatory cytokine activity, and may inhibit neutrophil aggregation. 2002
2016 Oct 4;13(1):259. doi: 10.1186/s12974-016-0728-y.Zhang JQ, Wu XH, Feng Y, Xie XF, Fan YH, Yan S, Zhao QY, Peng C, You ZL.Acta Pharmacol Sin. 2002
informational and educational purposes only. Mefenamic acid should be used cautiously in patients with preexisting hematological disease (e.g., coagulopathy or hemophilia), active bleeding, such as intracranial bleeding or GI bleeding, or thrombocytopenia due to the effect of the drug on platelet function and vascular response to bleeding.
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Epub 2016 Jul 18.Wang YL, Han QQ, Gong WQ, Pan DH, Wang LZ, Hu W, Yang M, Li B, Yu J, Liu Q.J Neuroinflammation. 2066114-overview
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Diseases & Conditions
or vehicle for 14 days.
doi: 10.1016/j.brainres.2020.146846. Mefenamic acid (MA) and celecoxib are nonselective and selective inhibitors of cyclooxygenase (COX), respectively.
Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC 50 s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid.
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The mechanism of action of mefenamic acid, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). 2009 Jun 10;612(1-3):54-60. doi: 10.1016/j.ejphar.2009.03.076. Copyright © 2020.
Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. This website also contains material copyrighted by 3rd parties. eCollection 2018. 980222-overview
Unable to load your delegates due to an error Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2) May inhibit chemotaxis, may alter lymphocyte activity, decrease proinflammatory cytokine activity, and may inhibit neutrophil aggregation. Contact the applicable plan Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs, and is used to treat mild to moderate pain, including menstrual pain, and is sometimes used to prevent migraines associated with menstruation.
Serious gastrointestinal bleeding, ulceration, and perforation: NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Sering digunakan sebagai obat sakit gigi, sakit kepala, dan meringankan rasa nyeri pada saat menstruasi.
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with strong analgesic activity.
Meclofenamate has a higher degree of COX-2 selectivity in dogs than many other NSAIDs, but is still less COX-2 selective than carprofen (Streppa et al., 2002).
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2010
Mefenamic acid is used routinely in clinical practice and so we tested the effects of mefenamic acid in an in vivo model of Aβ-induced memory loss 29.
2016 Sep;37(9):1141-53. doi: 10.1038/aps.2016.63. Asam mefenamat, atau mefenamic acid, adalah obat untuk mengobati rasa sakit ringan hingga sedang. and formulary information changes.
Asam mefenamat atau mefenamic acid dikenal sebagai nonsteroidal anti-inflammatory drug.