If you believe you are experiencing an interaction, contact a healthcare provider immediately. See our Network with colleagues and access the latest research in your fieldLaunch and grow your career with career services and resourcesPromoting excellence in science education and outreachFind a chemistry community of interest and connect on a local and global level.Explore the interesting world of science with articles, videos and more.Recognizing and celebrating excellence in chemistry and celebrate your achievementsFunding to support the advancement of the chemical sciences through research projects.ACS is committed to helping combat the global COVID-19 pandemic with initiatives and free resources. Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. To help you remember, take it at the same time each day. 305.32. To get the best possible experience using our website, we recommend that you upgrade to latest version of this browser or install another web browser. Torasemide is a high-ceiling loop diuretic. On the FDA records, torasemide was developed and first introduced by the company Teva Pharmaceuticals and FDA approved in 2002. 435.52. 294.35000000000002. But the medicine is not toxic unless the patient consumes 5–10 times the normally prescribed dosage.Learn how ACS can help you stay ahead in the world of chemistry.1155 Sixteenth Street, NW, Washington, DC 20036, USA | For your security, this online session is about to end due to inactivity.If you do not respond, everything you entered on this page will be lost and you will have to login again. CAS Reg. Chemsrc provides Mirabegron(CAS#:223673-61-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. This effect is suggested to be related to the decrease in aldosterone which in order has been shown to reduce the production of the enzyme procollagen type I carboxy-terminal proteinase which is known to be overexpressed in heart failure patients.As mentioned above, torasemide is part of the loop diuretics and thus, it acts by reducing the oxygen demand in the medullary thick ascending loop of Henle by inhibiting the Na+/K+/Cl- pump on the luminal cell membrane surface.Torasemide is known to have an effect in the renin-angiotensin-aldosterone system by inhibiting the downstream cascade after the activation of angiotensin II. Find patient medical information for Propranolol Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. 194.23. From this condition, it has been observed that torasemide is very effective in cases of kidney failure.Edema is considered when swelling is observed due to the trap of fluid in the body tissue. 298.36. Myrbetriq (mirabegron): “I've been dealing with nocturia and a weakened stream for almost a year. It is taken by mouth. This inhibition will produce a secondary effect marked by the reduction of the expression of aldosterone synthase, TGF-B1 and thromboxane A2 and a reduction on the aldosterone receptor binding.Torasemide is the diuretic with the highest oral bioavailability even in advanced stages of chronic kidney disease.The volume of distribution of torasemide is 0.2 L/kg.Torasemide is found to be highly bound to plasma proteins, representing over 99% of the administered dose.Torasemide is extensively metabolized in the liver and only 20% of the dose remains unchanged and it is recovered in the urine.Torasemide is mainly hepatically processed and excreted in the feces from which about 70-80% of the administered dose is excreted by this pathway. InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)1-({4-[(3-methylphenyl)amino]pyridin-3-yl}sulfonyl)-3-(propan-2-yl)ureaContact us to learn more about our customized products and solutions.As part of our commitment to providing the most up-to-date drug information, we will be releasing secondary amino compound, aminopyridine, N-sulfonylurea ( This effect is obtained by increasing urine output and hence, facilitating fluid, acid-base and potassium control. 338.4. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these unlikely but serious side effects occur: blue fingers/toes, mental/mood changes (e.g., Tell your doctor right away if any of these rare but very serious side effects occur: easy bruising/bleeding, signs of infection (e.g., fever, persistent This is not a complete list of possible side effects. 273.24. It is taken by mouth. melt wiht highest melting point first. Mirabegron(YM178) is a selective ?3-adrenoceptor agonist with EC50 of 22.4 nM. It had gotten to the point of having a constant urge to go when lying down, so I was getting very little sleep and turning into a zombie.