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If there is no obvious improvement, or there is evidence of progressive fungal disease, the dose should be increased in 100-mg increments to a maximum of 400 mg daily.
Memantine/Namenda Oral Sol: 5mL, 10mg Memantine/Namenda Oral Tab: 5mg, 10mg, 5-10mg Memantine/Namenda XR Oral Cap ER: 7mg, 14mg, 21mg, 28mg, 7-14-21-28mg The duration of therapy is dependent on clinical improvement and may take several weeks. Concomitant methadone, disopyramide, dofetilide, dronedarone, quinidine, isavuconazole, ergots, irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ivabradine, ranolazine, eplerenone, cisapride, naloxegol, lomitapide, lovastatin, simvastatin, avanafil, ticagrelor. 0000006629 00000 n
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Sporanox. 0000001993 00000 n
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The recommended dose is 200 mg once daily (2 capsules). Serious cardiac effects with cisapride, pimozide, methadone, quinidine, others.
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Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide, or levacetylmethadol® (levomethadyl) with SPORANOX (itraconazole) Capsules, Injection or Oral Solution is contraindicated. The dose usually is increased to 5 mg twice daily, then 5 mg and 10 mg as separate doses daily, and finally 10 mg twice daily. The starting dose is usually 5mg each day, in the morning. encoded search term (itraconazole (Sporanox%2C Onmel%2C Tolsura)) and itraconazole (Sporanox, Onmel, Tolsura) New FDA Watch List Has Insulin Pens, Muscle Relaxants, and MoreDrug Safety Warnings and Updates: October-December 2017Abuse, Misuse of Antidiarrheal Linked to Serious Heart ProblemsWhat Is the Risk of Catching the Coronavirus on a Plane?COVID-19 Antibodies Can Disappear After 2-3 Months, Study ShowsHydroxychloroquine RCTs: 'Ethically, the Choice Is Clear'Wear a Mask While Having Sex, Canada's Top Doctor SuggestsShare cases and questions with Physicians on Medscape consult. 0000006399 00000 n
Initially 10 mg daily, then increased to 40 mg daily, over 1 week; increased if necessary to 60 mg daily, over 1 week, on specialist advice only. 0000024144 00000 n
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mcg/mL (fed)Trough plasma concentration: 1.2 mcg/mL (Tolsura 130 mg BID); 1 mcg/mL (itraconazole 200 mg BID)Peak plasma concentration (steady-state): 1.6 mcg/mL (Tolsura 130 mg BID); 1.5 mcg/mL (itraconazole 200 mg BID)Peak plasma concentration (Onmel): 162 ng/mL (fasted); 213 ng/mL (fed)Peak plasma time (steady-state): 7 hr (Tolsura 130 mg BID); 5 hr (itraconazole 200 mg BID)Peak plasma time (Onmel): 2.9 hr (fasted); 5.7 hr (fed)Extensively metabolized by the liver into a large number of metabolitesMain metabolite is hydroxy-itraconazole, which has in vitro antifungal activity comparable to itraconazole; trough plasma concentrations of this metabolite are about twice those of itraconazoleAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans.