Although smaller doses of chemotherapy are given to pets, that doesn’t mean that your pet will not have side effects from the treatment. Splenic hemangiosarcoma is a malignant neoplasm of vascular endothelial origin which occurs more frequently in dogs than in any other species 1.It is diagnosed in middle aged to older dogs with the following breeds over-represented in published studies: German Shepherds, Golden Retrievers, Labrador Retrievers 1.. Increasing evidence suggests that dysregulation of molecular pathways … Do not use in pets that are allergic to it or other alkylating medications, that have bone marrow disease, have an active infection, or that are pregnant or lactating. You Tripawds peeps are the BEST!!!!!! Metronomic chemotherapy usually consists of low dose oral cyclophosphamide or chlorambucil plus a nonsteroidal anti-inflammatory drug (NSAID). There are a lot of studies about Cytoxan that shows it is anti-angiogenic when used in a metronomic fashion. A final analysis was performed by evaluating dogs which received any form of metronomic chemotherapy (ML, cyclophosphamide, or chlorambucil) compared to dogs which received no ML and no other form of chemotherapy (metronomic or MTD, P = 0.95). There are no studies in any species (humans, mice, dogs, cats, etc) about its potential to slow or prevent tumor angiogenesis which is what metronomic chemotherapy is supposed to do. It’s like comparing apples and oranges and bananas. There are some studies just starting now with Leukeran so I’d imagine in a year or two we will know more about this drug and whether it has any metronomic properties.We’d like to thank Dr. Biller for her time in helping us discover as much as possible about fighting cancer in our dogs and cats with metronomic chemotherapy. There are also many options to help lessen the side effects for your pet while he or she is under going treatment. No one knows what the metronomic dose of Leukeran would be in any species so you can’t even really guess.Leukeran is very much more expensive than Cytoxan and we don’t know if it works in a metronomic fashion. Let’s hope all of us using it find that it does, at least, no harm! Metronomic administration of chlorambucil may be a treatment option for dogs with TCC. Thanks, tripawd leaders!terrific article! Symptoms of SHC include pollakiuria, stranguria, and hematuria. im glad she says they are now doing some studies on leukeran! Metronomic chemotherapy is a hot topic among Tripawds members who are fighting cancer. This study supports the use of metronomic chlorambucil instead of cyclophosphamide to eliminate the risk of those side effects. In contrast to more traditional chemotherapy administered at maximally tolerated doses (MTD), the anticipated outcome with metronomic chemotherapy is disease stabilization or dormancy, therefore it is often pursued as a maintenance therapy, following surgery and/or MTD chemotherapy.Metronomic chemotherapy is well tolerated with minimal risk for bone marrow suppression or gastrointestinal (GI) upset. Chlorambucil is an immunosuppressant that is commonly prescribed by veterinarians to treat dogs and cats that are suffering from immune-mediated disorders and cancers, such as lymphoma and leukemia. No data for Alkeran as a metronomic agent exists that I am aware of.Obviously Cytoxan because there is human and dog data to tell us that it is anti-angiogenic when used in a metronomic fashion. Design-Prospective clinical trial. However, higher cumulative doses of Cytoxan have been associated with an increased risk of developing sterile hemorrhagic cystitis (SHC), which has been reported in 3.6 – 32% of dogs receiving metronomic cytoxan. 1, 2 Continuous administration of fixed, low doses of chemotherapy drugs without prolonged breaks in treatment (metronomic therapy) has been shown to be an effective means of inhibiting tumor angiogenesis, based primarily on studies in mice. Metronomic chemotherapy (MC) is the oral administration of anticancer drugs at low, minimally toxic doses on a frequent or continuous schedule. It is reasonably well tolerated with survival statistics similar to traditional intravenous cytotoxic chemotherapy [ 2 ].