It has been associated with a possible increased risk of various neuropsychiatric events in post-marketing analyses of … Epub 2015 Feb 12.Knorr B, Franchi LM, Bisgaard H, Vermeulen JH, LeSouef P, Santanello N, Michele TM, Reiss TF, Nguyen HH, Bratton DL.Pediatrics. Epub 2019 Jun 8.J Pediatr. Its labeling and the labels of the other leukotriene receptor antagonists, zafirlukast (An FDA review identified 82 cases of completed suicide associated with use of montelukast, many of which were preceded by new-onset neuropsychiatric symptoms. 2017 Aug 17;50(2):1700148. doi: 10.1183/13993003.00148-2017. Study design: A matched, nested case-control design was used to identify cases and controls from a cohort of children aged 5-18 years with physician-diagnosed asthma from 2004 to 2015, in Ontario, Canada, prescribed an asthma maintenance medication. Its labeling and the labels of the other leukotriene receptor antagonists, zafirlukast (Accolate, and generics) and zileuton (Zyflo, and generics), which are approved only for treatment of asthma, have included warnings about a risk of neuropsychiatric events since 2009. This site needs JavaScript to work properly. 2008;30 Spec No:1026-35. doi: 10.1016/j.clinthera.2008.05.018.Drugs. Neuropsychiatric disorders as side effects of montelukast were more frequently reported for children than for adults. Montelukast (a leukotriene receptor antagonist) is a commonly prescribed medication used in the management of asthma in both children and adults. Exploring the possible association between montelukast and neuropsychiatric events among children with asthma: a matched nested case‐control study. The FDA is requiring stronger warnings in the labeling of the leukotriene receptor antagonist montelukast (Montelukast has been FDA-approved for treatment of asthma and allergic rhinitis for many years. COVID-19 is an emerging, rapidly evolving situation. eCollection 2020. Unable to load your collection due to an error Name must be less than 100 characters A review of voluntary adverse event reports found that asthma medication montelukast was linked to increased reports of depression and nightmares in adults and children, and aggression in children. MHRA/CHM advice: Montelukast (Singulair®): reminder of the risk of neuropsychiatric reactions (September 2019) Healthcare professionals are advised to be alert for neuropsychiatric reactions, including speech impairment and obsessive-compulsive symptoms, in adults, adolescents, and children taking montelukast. Montelukast has been FDA-approved for treatment of asthma and allergic rhinitis for many years. In total, 898 cases with a neuropsychiatric event and 3497 matched controls were included. doi: 10.1542/peds.108.3.e48.Benard B, Bastien V, Vinet B, Yang R, Krajinovic M, Ducharme FM.Eur Respir J. Objective: To examine the association between montelukast prescription and neuropsychiatric events in children with asthma. Children who experienced a new-onset neuropsychiatric event had nearly 2 times the odds of having been prescribed montelukast, compared with controls (OR 1.91, 95% CI 1.15-3.18; P = .01). 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