For pharmacy processing assistance or questions, please call the Help Desk at When narrow angle glaucoma happens, it can be really scary. Narrow Angles and Angle-Closure Glaucoma What is Angle-Closure Glaucoma? This class of medication can affect eye pressure in people that have open-angle glaucoma, but can also raise eye pressure in those with the angle-closure form of the disease. This class of medication is used for many conditions, including:Short courses (1 to 2 weeks, for example) and lower doses of oral steroids decrease the risk of increased eye pressure. Many factors, including age, structural defects, damage to the trabecular meshwork and/or other drainage systems in the eye, aqueous humor overproduction, or blockages may be responsible for a rise in IOP. For example, monitor these patients for signs and symptoms of urinary retention. Worsening of hypertension was reported infrequently in Myrbetriq clinical trial patients with OAB.In patients taking Myrbetriq, urinary retention has been reported in patients with bladder outlet obstruction (BOO) and in patients taking antimuscarinic medications for the treatment of OAB. Do not use Myrbetriq ® (mirabegron) in patients who have known hypersensitivity reactions to mirabegron or any component of the tablet.. Solifenacin succinate is contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and in patients with hypersensitivity to the product. Myrbetriq should also be administered with caution to patients taking antimuscarinic medications for the treatment of OAB, including solifenacin succinate.Angioedema of the face, lips, tongue and/or larynx has been reported with Myrbetriq and with solifenacin succinate. Cases of angioedema have been reported to occur hours after the first dose or after multiple doses. Mirabegron belongs to the family of medications called antispasmodics. Angle-closure glaucoma, the second most common type, is a largely inherited disorder caused by a too-narrow angle in the passageway where aqueous fluid would normally drain.This type of glaucoma may occur in two ways: The chronic type progresses slowly and, like open-angle glaucoma, can result in optic nerve damage. For the 10mg dose, three intestinal serious adverse events were reported (one fecal impaction, one colonic obstruction and one intestinal obstruction).In clinical trials, the most commonly reported adverse reactions (> 2% and > placebo) for Myrbetriq 25mg and 50mg versus placebo, respectively, were hypertension (11.3%, 7.5% vs. 7.6%), nasopharyngitis (3.5%, 3.9% vs. 2.5%), urinary tract infection (4.2%, 2.9% vs. 1.8%), and headache (2.1%, 3.2% vs. 3.0%).In clinical trials, the most commonly reported adverse reactions (> 2% and > placebo and > comparator) for Myrbetriq in combination with solifenacin succinate 25mg + 5mg and 50mg + 5mg versus Myrbetriq 25mg, Myrbetriq 50mg, solifenacin succinate 5mg and placebo, respectively, were dry mouth (9.3%, 7.2% vs. 3.8%, 3.6%, 6.5%, 2.2%), urinary tract infection (7.0%, 4.0% vs. 4.0%, 4.2%, 3.6%, 5.3%), constipation (4.2%, 3.9% vs. 1.2%, 2.8%, 2.4%, 1.2%), and tachycardia (2.2%, 0.9% vs. 1.6%, 1.6%, 0.7%, 0.8%).In postmarketing experience with mirabegron, the following events have also occurred: atrial fibrillation, nausea, constipation, diarrhea, and dizziness.The information contained on this site is intended for You are now leaving myrbetriqhcp.com. This article explores the classes of medications that may affect the open-angle and angle-closure forms of glaucoma. University of California, San Francisco, UCSF Medical CenterMany different drugs have the potential to elevate eye pressure and increase the risk of developing glaucoma. Myrbetriq is not recommended for use in severe uncontrolled hypertensive patients (defined as systolic blood pressure ≥ 180mm Hg and/or diastolic blood pressure ≥ 110mm Hg). People with "narrow angle glaucoma" may have risk of acute angle closure glaucoma wit these medications. If you do not know your status, please consult with your eye doctor. Angioedema associated with upper airway swelling may be life threatening. If a patient experiences these effects, dose reduction or drug discontinuation should be considered.Since Myrbetriq is a moderate CYP2D6 inhibitor, the systemic exposure to CYP2D6 substrates such as metoprolol and desipramine is increased when co-administered with Myrbetriq. This website is funded and developed by Astellas Pharma US, Inc. Myrbetriq is a registered trademark of Astellas Pharma Inc.By clicking “Continue,” you will leave MyrbetriqHCP.com and enter astellasmedinfo.com. This is a chronic, slowly-progressing condition. Periodic blood pressure determinations are recommended, especially in hypertensive patients. Most pharmacies will give you the opportunity to speak with a pharmacist about your medications. She also has constant dry mouth. All rights reserved.The first few weeks after a diagnosis can be overwhelming, and leave you with many questions and concerns. Common examples of these medication include Claritin (Loratadine), Sudafed, Allegra (fexofenadine), Singulair, Benadryl (Diphenhydramine), and Zyrtec.