This information is intended for use by health professionalsKetoconazole 2% w/w (each gram of cream contains 20mg).propylene glycol, 20%w/w (each gram of cream contains 200mg).stearyl alcohol, 7.5%w/w (each gram of cream contains 75mg).cetyl alcohol, 2.0%w/w (each gram of cream contains 20mg).For topical application in the treatment of dermatophyte infections of the skin such as tinea corporis, tinea cruris, tinea manus and tinea pedis infections due to Trichophyton spp, Microsporon spp and Epidermophyton spp. It is, therefore, advisable to monitor digoxin concentrations in patients receiving ketoconazole.Telithromycin: A multiple-dose interaction study with ketoconazole showed that CCilostazol: Concomitant administration of single doses of cilostazol 100 mg and ketoconazole 400 mg approximately doubled cilostazol concentrations and altered (increase/decrease) the concentrations of the active metabolites of cilostazol.Coumarins: Ketoconazole may enhance the anticoagulant effect of coumarin-like drugs, thus the anticoagulant effect should be carefully titrated and monitored.Dabigatran: In patients with moderate renal impairment (CrCL 50 mL/min to ≤ 80 mL/min), consider reducing the dose of dabigatran to 75 mg twice daily when it is coadministered with ketoconazole.Ergot alkaloids: The potential increase in plasma concentrations of ergot alkaloids when coadministered with NizoralEletriptan: Eletriptan should be used with caution with ketoconazole, and specifically, should not be used within at least 72 hours of treatment with ketoconazole.Irinotecan: The potential increase in plasma concentrations of irinotecan when coadministered with NizoralDocetaxel: In the presence of ketoconazole, the clearance of docetaxel in cancer patients was shown to decrease by 50%.Alprazolam, midazolam, triazolam: Coadministration of NizoralPimozide: The potential increase in plasma concentrations of pimozide when coadministered with NizoralAripiprazole: Coadministration of ketoconazole (200 mg/day for 14 days) with a 15 mg single dose of aripiprazole increased the AUC of aripiprazole and its active metabolite by 63% and 77%, respectively. It allows continued monitoring of the benefit/risk balance of the medicinal product. The cap is made of 60% polypropylene, 30% calcium carbonate and 10% glyceryl monostearate.50 - 100 Holmers Farm Way, High Wycombe, Bucks, HP12 4EGTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. Available for Android and iOS devices. Mothers who are under treatment with NizoralBecause clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.The following adverse reactions were reported in clinical trials:The following adverse reactions have been identified during postapproval use of NizoralThe following adverse reactions were reported during post-marketing experience:In the event of acute accidental overdose, treatment consists of supportive and symptomatic measures. When using concomitant medication, the corresponding label should be consulted for information on the route of metabolism and the possible need to adjust dosages.Interaction studies have only been performed in adults. Healthcare professionals are asked to report any suspected adverse reactions via:Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.Excessive topical application may lead to erythema, oedema and a burning sensation, which will disappear upon discontinuation of the treatment.In the event of accidental ingestion, supportive and symptomatic measures should be carried out.Usually ketoconazole cream acts rapidly on pruritus, which is commonly seen in dermatophyte and yeast infections, as well as skin conditions associated with the presence of Malassezia spp. See The Nizoral brand name has been discontinued in the U.S. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. ).Ketoconazole has been used in high doses for the treatment of advanced prostate cancer and for Cushing's syndrome when other treatment options have failed.