Also, blood will be drawn and stored for possible measurement of drug levels, after 4 and 8 weeks on each drug. You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more.Participants first received Nebivolol at a dose of 5 mg daily for 4 weeks, followed by 10 mg daily for another 4 weeks (i.e., weeks 1-8 in total). It is well-established that beta-blockers cause fatigue in many patients and reduce exertion tolerance. 31 subjects received Metoprolol 100 mg daily for 4 weeks Methods: This is a prospective, double-blind, randomized, two arms trial. Fatigue is a recognized and common side effect of beta-blockers that can have significant effects on quality of life. Statistical Test For nebivolol, dosage will be 5 mg daily for 4 weeks and 10mg daily for 4 weeks. COVID-19 is an emerging, rapidly evolving situation. Nebivolol 5 mg for 4 Weeks All participants who received both interventions and completed all study visits were included in the efficacy analysis. Principal Investigators are NOT employed by the organization sponsoring the study. You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more. COVID-19 is an emerging, rapidly evolving situation. The participants then received Metoprolol at a dose of 50 mg daily for 4 weeks, followed by 100 mg daily for another 4 weeks (i.e., weeks 9-16 in total).Participants first received Metoprolol at a dose of 50 mg daily for 4 weeks, followed by 100 mg daily for another 4 weeks (i.e., weeks 1-8 in total). Nebivolol 10 mg for 4 Weeks Nevertheless, the known hemodynamic differences between nebivolol and other beta-blockers, and the positive clinical experience, warrant formal study to determine whether nebivolol is kinder than other beta-blockers in terms of the important side effect of fatigue.A 16 item scale that measures 4 dimensions of fatigue: severity, distress, timing, and degree of interference in activities of daily living. Statistical Test The symptom ceased with discontinuation of the drug. to 94.92 Studies indicate that nebivolol, unlike most beta-blockers, does not cause constriction of peripheral blood vessels, and is associated with improved heart function (2). Subjects will undergo a treadmill stress test and will complete fatigue and quality of life questionnaires after each 4 weeks of treatment. Results on each drug will then be compared. Metoprolol succinate will be given at a dose of 50 mg daily for 4 weeks, then 100 mg daily for 4 weeks. Estimation Comments the PI's rights to discuss or publish trial results after the trial is completed. The purpose of this study is to compare nebivolol with the current best-selling beta-blocker, metoprolol, and determine whether there is a significant difference in side effects including fatigue, reduced exertion tolerance, and reduced quality of life.In this study, 30 subjects will take each of the 2 study drugs for 8 weeks, consisting of 4 weeks at a lower dose, and 4 weeks at a higher dose. In many, it reduces cardiac output and increases peripheral resistance to blood flow (1). 31 subjects received Nebivolol 5 mg daily for 4 weeks. Metoprolol 50 mg for 4 Weeks We aim to compare effects of two BB -Metoprolol and Nebivolol, a third generation BB with vasodilatory property mediated by nitric oxide release, on blood pressure (BP) control. [ not Specified ] All participants who received both interventions and completed All study visits were as! 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