Be alert for complaints of estrogen-related side effects (e.g., nausea, fluid retention, breast tenderness). Dis Colon Rectum 19 (1976): 618-2031. Breast Pain 2. Ann Intern Med 136 (2002): 680-9027. "Product Information. N Engl J Med 330 (1994): 1062-7130. Wren BG, Routledge DA "Blood pressure changes: oestrogens in climacteric women." OrrWalker BJ, Horne AM, Evans MC, Grey AB, Murray MAF, McNeil AR, Reid IR "Hormone replacement therapy causes a respiratory alkalosis in normal postmenopausal women." But the likely cause of abnormal uterine bleeding depends on your age. Side effects requiring immediate medical attention. Ann Allergy 72 (1994): 33-545. N Engl J Med 325 (1991): 756-6214. Crane MG, Harris JJ "Estrogens and hypertension: effect of discontinuing estrogens on blood pressure, exchangeable sodium, and the renin-aldosterone system." Steiger MJ, Quinn NP "Hormone replacement therapy induced chorea." adverse reactions have been identified during post-approval use of PREMARIN. Belchetz PE "Hormonal treatment of postmenopausal women." elsewhere in labeling:Because clinical trials are conducted under widely Gapstur SM, Morrow M, Sellers TA "Hormone replacement therapy and risk of breast cancer with a favorable histology: results of the Iowa women's health study." Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … Arch Intern Med 162 (2002): 1409-1537. Hoover R, Glass A, Finkle WD, Azevedo D, Milne K "Conjugated estrogens and breast cancer risk in women." Palmer JR, Rosenberg L, Clarke EA, Miller DR, Shapiro S "Breast cancer risk after estrogen replacement therapy: results from the Toronto Breast Cancer Study." N Engl J Med 300 (1979): 9-13Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. Schwartz J, Freeman R, Frishman W "Clinical pharmacology of estrogens: cardiovascular actions and cardioprotective benefits of replacement therapy in postmenopausal women." Lindsay R, Gallagher JC, Kleerekoper M, Pickar JH "Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women." O 017. Perusse R, Morency R "Oral pigmentation induced by Premarin." Kaufman DW, Palmer JR, de Mouzon J, Rosenberg L, Stolley PD, Warshauer ME, Zauber AG, Shapiro S "Estrogen replacement therapy and the risk of breast cancer: results from the case-control surveillance study." Mendelsohn ME, Karas RH "The protective effects of estrogen on the cardiovascular system." Acta Obstet Gynecol Scand 58 (1979): 12358. establish a causal relationship to drug exposure.Nausea, vomiting, abdominal McClennan BL "Ischemic colitis secondary to Premarin: report of a case." Ann Intern Med 130 (1999): 262-964. This is not a complete list of side effects and others may occur. Cerner Multum, Inc. "Australian Product Information." JAMA 280 (1998): 605-1322. "The use of estrogens and progestins and the risk of breast cancer in postmenopausal women." This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Bergkvist L, Adami HO, Persson I, Hoover R, Schairer C "The risk of breast cancer after estrogen and estrogen-progestin replacement." In the Million Women Study 5 years of HRT resulted in 1 extra case per 2500 users.1. Am J Epidemiol 114 (1981): 497-50646. Sidney S, Petitti DB, Quesenberry CP "Myocardial infarction and the use of estrogen and estrogen-progestogen in postmenopausal women." Collins P, Beale CM, Rosano GMC "Oestrogen as a calcium channel blocker." Swelling Of The Abdomen Premarin may interact with blood thinners, The Writing Group for the PEPI Trial "Effects of hormone replacement therapy on endometrial histology in postmenopausal women." Ziel HK, Finkle WD "Increased risk of endometrial carcinoma among users of conjugated estrogens." "Product Information. Eur Heart J 17 ( Suppl (1996): 27-313. "Effects of estrogen and estrogen-progestin on mammographic parenchymal density." Headache 2. These are just a few of the problems that can cause abnormal uterine bleeding. N Engl J Med 343 (2000): 522-910. Although not all of these side effects may occur, if they do occur they may need medical attention. Dosage adjustment may be made based on patient response. that occurred at a rate of ≥ 1 percent in any treatment group.The following additional Jick H, Dinan B, Rothman KJ "Noncontraceptive estrogens and nonfatal myocardial infarction."