This is the new name for bendrofluazide. Cardiac output is gradually restored, but the hypotensive effect remains, possibly because of the reduced peripheral resistance of vessels. It may result from reduced CaThese drugs produce their maximum BP-lowering effect at doses lower than those required for significant diuretic activity. At the beginning of therapy this leads to a decrease in plasma volume, loss of potassium, and inhibition of the excretion of uric acid.Benzothiazides are well resorbed in the intestinal tract and excreted unchanged in urine. Do not stand or sit up quickly, especially if you are an older patient. However, when a diuretic is urgently needed, moderately dosed treatment with hydrochlorothiazide can be considered. Do not use sun lamps or tanning beds/booths.Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. However, compensatory mechanisms such as activation of the renin–angiotensin–aldosterone system largely restore plasma and extracellular fluid volumes (see Direct arterial dilation is responsible for the longer-term reduction in BP. This is of importance in the treatment of older patients who have isolated systolic hypertension.Low-dose diuretics may be given in combination with beta blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, or other drugs with excellent BP-reducing effects (A potassium-sparing diuretic should be used with caution in patients who have reduced renal function or diabetes, especially if they are also receiving an ACE inhibitor or ARB.We use cookies to help provide and enhance our service and tailor content and ads. What is this medicine? How should I use this medicine? Bendroflumethiazide. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Take your doses at regular intervals. This is an advantage, since most unwanted effects are dose-related. Later, volume rises toward normal and cardiac output normalizes. Bendroflumethiazide may be used for the same indications as the aforementioned drugs; however, it is primarily used as an adjuvant agent for relieving edema associated with cardiac insufficiency, liver cirrhosis, and edema caused by taking corticosteroids. Sign In. It may not cover all possible information. However, at low doses, e.g. Take this medicine by mouth with a glass of water. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. However, hypertension with advanced chronic kidney disease or hypertension resistant to multiple drug treatment is more likely to be associated with fluid retention and often responds better to a loop diuretic than to a thiazide.Spironolactone, a specific aldosterone antagonist, is particularly effective for hypertension caused by primary hyperaldosteronism (Conn's syndrome). Special care may be needed.Side effects that you should report to your doctor or health care professional as soon as possible:allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongueredness, blistering, peeling or loosening of the skin, including inside the mouthSide effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):MAOIs like Carbex, Eldepryl, Marplan, Nardil, and ParnateNSAIDs, medicines for pain and inflammation, like ibuprofen or naproxenIf you miss a dose, take it as soon as you can. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. If it is almost time for your next dose, take only that dose. Avoid excessive heat. Chlortalidone is contraindicated because of its high relative dose. It is used to treat high blood pressure. It is also possible that diuretics somehow lower vascular activity of noradrenaline and other factors of pressure in the organism. Bendroflumethiazide, 1,1-dioxide 3-benzyl-6-(trifluoromethyl)-3,4-dihydro-2 H-1,2,4-benzothiadiazin-7-sulfonamide (21.3.6), is synthesized by the same scheme of making the aforementioned drugs using phenylacetaldehyde or its acetale as a carbonyl component, and using 2,4-disulfonamido-5-trifluoromethylaniline (21.3.5) as an o-aminosulfonamide component [18–21]. If you have diabetes, check with your doctor or health care professional before changing the dose of your diabetic medicine.This medicine can make you more sensitive to the sun.