And if you become pregnant while taking this drug, call your doctor right away. These drugs are often used to treat similar conditions.Risperidone works by affecting the amount of certain chemicals called neurotransmitters that occur naturally in your brain. The volume of distribution is 1 to 2 L/kg. A Cochran-Armitage Test for trend in these data revealed a positive trend (p<0.05) for the following adverse reactions: somnolence, vision abnormal, dizziness, palpitations, weight increase, erectile dysfunction, ejaculation disorder, sexual function abnormal, fatigue, and skin discoloration.Weight gain was observed in short-term, controlled trials and longer-term uncontrolled studies in adult and pediatric patients Between-group comparisons for pooled placebo-controlled trials in adults revealed no statistically significant differences between Risperidone and placebo in mean changes from baseline in ECG parameters, including QT, QTc, and PR intervals, and heart rate. In 2010, poison control centres in the US received nearly 43000 calls related to atypical antipsychotics alone. This is because the amount of risperidone in your body may be decreased. Risperidone is a medication that works in the brain to treat schizophrenia. Talk to your doctor about other drug options that may work for you.© 2005-2020 Healthline Media a Red Ventures Company. The pharmacokinetics of Risperidone and 9-hydroxyRisperidone combined, after single and multiple doses, were similar in extensive and poor metabolizers, with an overall mean elimination half-life of about 20 hours.In healthy elderly subjects, renal clearance of both Risperidone and 9-hydroxyRisperidone was decreased, and elimination half-lives were prolonged compared to young healthy subjects. WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSISElderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Our website services, content, and products are for informational purposes only. Torsade de pointes has been reported in association with combined overdose of Risperidone and paroxetine.Risperidone tablets are for oral administration and available in 0.25 mg (yellow), 0.5 mg (brown), 1 mg (white), 2 mg (orange), 3 mg (yellow), and 4 mg (green) strengths. The CGI-C rating at endpoint was a co-primary outcome measure in one of the studies.There were two weight-based, fixed doses of Risperidone (high-dose and low-dose). The efficacy on the primary parameter in the 3 to 6 mg/day dose group was comparable to the 0.5 to 2.5 mg/day dose group. It shouldn’t be used in this age group.Your doctor may give you a lower starting dosage of 0.5 mg taken twice per day. In some cases, hyperglycemia has resolved when the atypical antipsychotic, including Risperidone, was discontinued; however, some patients required continuation of anti-diabetic treatment despite discontinuation of Risperidone.Pooled data from three double-blind, placebo-controlled schizophrenia studies and four double-blind, placebo-controlled bipolar monotherapy studies are presented in Table 2.Data from the placebo-controlled 3- to 6-week study in children and adolescents with schizophrenia (13 to 17 years of age), bipolar mania (10 to 17 years of age), or autistic disorder (5 to 17 years of age) are presented in Table 3.Undesirable alterations in lipids have been observed in patients treated with atypical antipsychotics.Pooled data from 7 placebo-controlled, 3- to 8- week, fixed- or flexible-dose studies in adult subjects with schizophrenia or bipolar mania are presented in Table 4.Pooled data from 3 placebo-controlled, 3- to 6-week, fixed-dose studies in children and adolescents with schizophrenia (13 to 17 years of age), bipolar mania (10 to 17 years of age), or autistic disorder (5 to 17 years of age) are presented in Table 5.Weight gain has been observed with atypical antipsychotic use. Otherwise, call a poison control center right away. They may increase your dosage more slowly to reduce your risk of side effects.This medication hasn’t been studied in children younger than 10 years. Your dosage, drug form, and how often you take the drug will depend on:This medication hasn’t been studied in children younger than 13 years. However, there was a 20% increase in valproate peak plasma concentration (CRisperidone (0.25 mg twice daily) did not show a clinically relevant effect on the pharmacokinetics of digoxin. The relative oral bioavailability of Risperidone from a tablet is 94% (CV=10%) when compared to a solution.Pharmacokinetic studies showed that Risperidone orally disintegrating tablets and Risperidone oral solution are bioequivalent to Risperidone tablets.Plasma concentrations of Risperidone, its major metabolite, 9-hydroxyRisperidone, and Risperidone plus 9-hydroxyRisperidone are dose proportional over the dosing range of 1 to 16 mg daily (0.5 to 8 mg twice daily).