Weidner N, Smith J, Pattee B. Sulfasalazine in treatment of collagenous colitis: case report and review of the literature. More severe reactions to SSZ, likely due to hypersensitivity/allergic responses, can occur and include rashes (which can progress to Stevens-Johnson syndrome), fever, hepatitis, pneumonitis, and aplastic anemia. Approximately 60% of the Caucasian population can be classified as belonging to the slow acetylator phenotype. 135. Baiocco PJ, Korelitz BI. ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B9780323244855005337URL: https://www.sciencedirect.com/science/article/pii/B9780323316965000619URL: https://www.sciencedirect.com/science/article/pii/B9780323036221500318URL: https://www.sciencedirect.com/science/article/pii/B9780323054751500458URL: https://www.sciencedirect.com/science/article/pii/B9780323044042100909URL: https://www.sciencedirect.com/science/article/pii/B9780444638878000037URL: https://www.sciencedirect.com/science/article/pii/B9780128033029000026URL: https://www.sciencedirect.com/science/article/pii/B9780128169926000036URL: https://www.sciencedirect.com/science/article/pii/B978070202858850021XURL: https://www.sciencedirect.com/science/article/pii/B9781416060680000206Saunders Handbook of Veterinary Drugs (Fourth Edition)Kelley and Firestein's Textbook of Rheumatology (Tenth Edition)Other Traditional Disease-Modifying Antirheumatic Drugs: Monotherapy and Combination TherapyAnti-inflammatory efficacy of some potentially bioactive natural products against rheumatoid arthritisDiscovery and Development of Anti-Inflammatory Agents from Natural ProductsSmall Animal Clinical Pharmacology (Second Edition)ScienceDirect ® is a registered trademark of Elsevier B.V. It is unclear exactly how it works. SSZ is cleaved in the large bowel into 5-aminosalicylic acid (5-ASA) and sulfapyridine. It acts in part as a tumour necrosis factor inhibitor. Warsof SL. It is often necessary to continue medication even when clinical symptoms, including diarrhea, have been controlled. The influence of inflammatory bowel disease and its treatment on pregnancy and fetal outcome. Mesalamine can potentially interfere with thiopurine methyltransferase and therefore increase the risk of toxicity from azathioprine.Sulfonamides may interact with other drugs, including warfarin, methenamine, dapsone, and etodolac. SP can also be metabolized to 5-hydroxy-sulfapyridine (SPOH) and N-acetyl-5-hydroxy-sulfapyridine. The clinical implication of this is unclear; however, in a small pharmacokinetic trial where acetylator status was determined, subjects who were slow acetylators of SP showed a higher incidence of adverse events.Gender appears not to have an effect on either the rate or the pattern of metabolites of SSZ, SP, or 5-ASA.Only after critical appraisal should Sulfasalazine tablets be given to patients with hepatic or renal damage or blood dyscrasias. The causal association of these findings with a clinical response to sulfasalazine remains unclearSSZ is a conjugate of 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP). 170. If idiosyncratic hypersensitivity/allergic reactions are suspected, SSZ should be stopped and not reintroduced. Sulfasalazine tablets contain Sulfasalazine, 500 mg, for oral administration.Therapeutic Classification: Anti-inflammatory agent.Chemical Designation: 5-([p-(2-pyridylsulfamoyl)phenyl]azo) salicylic acid.Chemical Structure:Molecular Formula: C18H14N4O5SInactive Ingredients: magnesium stearate, povidone, silica (colloidal anhydrous), starch (pregelatinized). Philadelphia, PA: WB Saunders; 2000:557-77.158. Br J Rheumatol 1995; 34 Suppl 2:7. Monitor human milk fed infants of mothers taking Sulfasalazine for signs and symptoms of diarrhea and/or bloody stools.Safety and effectiveness in pediatric patients below the age of 2 years have not been established.The most common adverse reactions associated with Sulfasalazine are anorexia, headache, nausea, vomiting, gastric distress, and apparently reversible oligospermia. Reversible male infertility due to sulphasalazine: studies in man and rat. Which component of sulphasalazine is active in rheumatoid arthritis? O’Morain C, Smethurst P, Dore CJ. Select one or more newsletters to continue. Arthritis Rheum 2004; 50:2130. 138. Rarely, SSZ can increase the effects of oral hypoglycemics and the anti-coagulant effects of warfarin. Vender RJ, Spiro HM. In more advanced cases, central nervous system symptoms such as drowsiness, convulsions, etc., may be observed. Newman NM, Correy JF. Sulfasalazine. Willoughby CP, Truelove SC. Rarely, SSZ can increase the effects of oral hypoglycemics and the anti-coagulant effects of warfarin. 114. SSZ is cleaved in the large bowel into 5-aminosalicylic acid (5-ASA) and sulfapyridine. The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces.