The chemical name of silodosin is (R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethylamino)propyl) indoline-7-carboxamide and the molecular formula is C Silodosin is a white to pale yellowish colour powder that melts at approximately 105 to 109°C. Copy the URL below and paste it into your RSS Reader application.DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed.DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. May 5, 2018 The applesauce used should not be hot, and it should be soft enough to be swallowed without chewing. In patients with moderate renal impairment (CCr 30-50 mL/min), the dose should be reduced to 4 mg once daily taken with a meal. Drug information provided by: IBM Micromedex. However, interactions may be expected, and silodosin should not be used in combination with other alpha-blockers [The effect of co-administration of silodosin and digoxin 0.25 mg/day for 7 days was evaluated in a clinical trial in 16 healthy males, aged 18 to 45 years. Patients planning cataract surgery should be told to inform their ophthalmologist that they are taking silodosin[No laboratory test interactions were observed during clinical evaluations. Concomitant administration of strong CYP3A4 inhibitors and silodosin is contraindicated [The pharmacodynamic interactions between silodosin and other alpha-blockers have not been determined. Call 040 - 67006700 for help. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by The primary efficacy assessment was the International Prostate Symptom Score (IPSS) which evaluated irritative (frequency, urgency, and nocturia), and obstructive (hesitancy, incomplete emptying, intermittency, and weak stream) symptoms. 33342-384-07, (• Strong P-glycoprotein inhibitors (e.g., cyclosporine): Co-administration may increase plasma silodosin concentration. Silodosin (Oral Route) Print. Safety and effectiveness in pediatric patients have not been established.In double-blind, placebo-controlled, 12-week clinical studies of silodosin, 259 (55.6%) were under 65 years of age, 207 (44.4%) patients were 65 years of age and over, while 60 (12.9%) patients were 75 years of age and over. Concomitant use is not recommended. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. As with other alpha-blockers, there is potential for syncope. B – Baseline determination taken Day 1 of the study before the initial dose. These changes are believed to produce specific morphological and functional changes in the rat thyroid including hypertrophy, hyperplasia, and neoplasia. [citation needed] Research. (• 8 mg capsules taken orally once daily with a meal. Drug interactions are reported among people who take Klonopin and Cardizem cd together. Back to Top. Silodosin an alpha-1 adrenergic receptor antagonist, is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). Sections. Browse products with compositon Silodosin-8-MG and there variants. Plasma concentrations of silodosin were approximately three times higher in subjects with moderate renal impairment compared with subjects with normal renal function.In a study comparing nine male patients with moderate hepatic impairment (Child-Pugh scores 7 to 9), to nine healthy male subjects, the single dose pharmacokinetics of silodosin were not significantly altered in patients with hepatic impairment. Silodosin is the brand name for silodosin, a selective antagonist of alpha-1 adrenoreceptors. MedPlus - Online Pharmacy Store in India. Please check with a physician if you have health questions or concerns. B – Baseline determination taken Day 1 of the study before the initial dose. Patients should be instructed to take silodosin once daily with a meal. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. Orthostatic hypotension was reported in 2.3% of silodosin patients < 65 years of age (1.2% for placebo), 2.9% of silodosin patients ≥ 65 years of age (1.9% for placebo), and 5.0% of patients ≥ 75 years of age (0% for placebo). Silodosin Brand Names. Never use this combination of drugs because of high risk for dangerous interactionPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be neededPotential for significant interaction (monitoring by your doctor is likely required)Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. eHealthMe has been monitoring drugs since 2008. Side Effects . Back to Top. It is taken by mouth or injection into a vein. (• Renal impairment: Dose adjustment in moderate disease (Silodosin, a selective alpha-1 adrenergic receptor antagonist, is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH) [The recommended dose is 8 mg orally once daily with a meal.Renal impairment: Silodosin is contraindicated in patients with severe renal impairment (CCr < 30 mL/min). Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes.