Please enable it to take advantage of the complete set of features! If you have liver cancer and are waiting for a liver transplant, you will take sofosbuvir with ribavirin for up to 48 weeks or until you have a liver transplant. The optimal duration of treatment and use of novel combinations with other DAAs should be examined in the future. In this case, taking sofosbuvir may increase the risk that you will develop symptoms and your infection will become more serious or life-threatening. Resistance to sofosbuvir did not appear as a significant issue. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea, vomiting, pale stools, stomach pain, or dark urine.Keep all appointments with your doctor and the laboratory. pharmacological class. Sofosbuvir is in a class of antiviral medications called nucleotide polymerase inhibitors. Talk with your doctor about safe ways to prevent HCV transmission during sex. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults and children at least 6 years old or weighing at least 82 pounds (37 kilograms). 2018 Oct 24;62(11):e01280-18. Published by Elsevier Ltd. All rights reserved. Do not share your medicine with other people.Sofosbuvir and velpatasvir is sometimes used in people who also have Sofosbuvir and velpatasvir may also be used for purposes not listed in this medication guide.If you have ever had hepatitis B, this medicine can cause the condition to come back or get worse. Drug interactions and pregnancy and breastfeeding safety should be discussed with your doctor before using this … If sofosbuvir is taken in combination with ribavirin alone, it is usually taken for 12 or 24 weeks. 2016 Apr 28;374(17):1687. doi: 10.1056/NEJMc1601160.N Engl J Med. Ledipasvir/sofosbuvir, sold under the trade name Harvoni among others, is a medication used to treat hepatitis C. It is a fixed-dose combination of ledipasvir and sofosbuvir. Sofosbuvir is an oral nucleoside analogue and potent inhibitor of the hepatitis C virus (HCV) RNA polymerase that is used in combination with other antiviral agents to treat chronic hepatitis C. Elevations in serum enzyme levels during sofosbuvir therapy are uncommon, and it has not been implicated convincingly in cases of clinically apparent liver injury with jaundice. Print 2018 Nov. Please enable it to take advantage of the complete set of features! Do not take more or less of it or take it more often than prescribed by your doctor.Sofosbuvir pellets can be swallowed (without chewing) or they can be taken with food. The pharmacokinetics of sofosbuvir were studied following 7-day dosing of 400 mg sofosbuvir in HCV-infected subjects with moderate and severe hepatic impairment (Child-Pugh Class B and C). Call your doctor for medical advice about side effects. You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage) but not have any symptoms of the disease. However, you should not flush this medication down the toilet. Sofosbuvir may not prevent the spread of hepatitis C to other people.Sofosbuvir comes as a tablet and pellets to take by mouth. Affiliations (Funded by Gilead Sciences; ASTRAL-4 ClinicalTrials.gov number, … To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach. 2020 Jun 30;10:325. doi: 10.3389/fcimb.2020.00325. Sofosbuvir was discovered in 2007, and approved for medical use in the United States in 2013. Do not take two doses at one time.Get your prescription refilled before you run out of medicine completely.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Using sofosbuvir and velpatasvir will not prevent your disease from spreading. COVID-19 is an emerging, rapidly evolving situation. Epub 2014 Aug 31.Clin Infect Dis. 2015 Dec 31;373(27):2608-17. doi: 10.1056/NEJMoa1512612. Unable to load your delegates due to an error 2020 Mar 16;2020:2781350. doi: 10.1155/2020/2781350. Name must be less than 100 characters Every person with chronic hepatitis C should remain under the care of a doctor.If you have ever had hepatitis B, using sofosbuvir and velpatasvir can cause this virus to become active or get worse. You may need frequent Store this medicine in the original container at room temperature away from moisture and heat.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Use only the medications prescribed for you. 2014 Feb;34(1):37-46. doi: 10.1055/s-0034-1371009.