You can also search for this author in However, the magnitude of the interaction with cyclosporine is much less than with the other azoles.Depending on the suspected pathogen, the interaction between the azoles and calcineurin inhibitors may be unavoidable. Pharmacotherapy. 2016;134(21):e468–95. Yasmine S. Ali, MD, MSCI, is a board-certified preventive cardiologist and lipidologist. Omar MA, Wilson JP. As mentioned before, the synthetic statins have been shown to be more effective at providing antifungal action than the fungal metabolites. 2002;46(1):49–53.Neuvonen PJ, Jalava K-M. Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid. This and more subtle differences motivated matching methods to obtain a more comparable no-statin group in order to reduce confounding and bias. Abstract. Circulation. Itraconazole reduces CYP3A4 metabolism and P‐gp efflux of vincristine. This review included original studies, scholarly reviews and relevant case reports.In humans, amphotericin B primarily distributes to the liver and, to a lesser extent, a variety of tissues including the spleen, kidneys and heart.In healthy volunteers, over 90% of a D‐AmB dose is accounted for 1 week after the administration. In addition, which activity predominates may be dose related. Am J Cardiol. 2015;35(11):1037–51.Thompson GR, Cadena J, Patterson TF. Statins are commonly prescribed to lower cholesterol levels. 1998;63(3):332–41.Yamazaki T, Desai A, Goldwater R, Han D, Lasseter KC, Howieson C, et al. Macrolides and selected antifungals can significantly increase drug levels of select statins, particularly those metabolized by the CYP3A4 pathway. Lexicomp's Drug Information Handbook. 2014;48(3):320–7.Department of Pharmacotherapy & Outcomes Science, Virginia Commonwealth University School of Pharmacy, 410 N. 12th St., PO Box 980533, Richmond, VA, 23298-0533, USALeigh Anne Hylton Gravatt, Rachel W. Flurie & Dave L. DixonDepartment of Clinical and Administrative Sciences, Howard University College of Pharmacy, Washington, DC, USAYou can also search for this author in Just because you are on any of these medications, it does not mean that you are not able to take a statin. Hudson, OH:Lexi-Comp Inc.; 2017. Similarly, they often are well aware of the potential toxicities of antifungal agents. This includes any medical conditions you may have or any medications you are taking. Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin. Daptomycin interacts with statins via additive skeletal muscle toxicity. Shapiro LE, Shear NH. J Am Coll Cardiol. For example, ritonavir is a protease inhibitor that is primarily metabolised by CYP3A4 and somewhat less by CYP2D6.The non‐nucleoside reverse transcriptase inhibitor efavirenz is primarily metabolised by CYP3A4 and CYP2B6 and undergoes subsequent glucuronidation. 2013;158(12):869. The echinocandins have the lowest propensity to interact with other medicines. Alert your doctor immediately if you develop warning signs of a liver problem such as loss of appetite, nausea, vomiting, or yellow skin or eyes.