Furthermore, telmisartan produced a significantly lower incidence of dry cough than lisinopril in patients with a history of ACE inhibitor-related cough in a study for which this parameter was the primary end-point (15.6 Telmisartan, alone and in combination with other antihypertensive agents, is indicated for the treatment of hypertension. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Pharmacology and antihypertensive effects of telmisartan, an ATWagner J, Drab M, Bohlender J, et al. P.47 and poster]. As a result of saturable first-pass metabolism, the oral bioavailability of telmisartan is dose dependent (42.4% after a single 40mg oral dose) and maximum plasma concentrations (CTelmisartan is extensively distributed to tissues (mean apparent volume of distribution at steady state was 460 to 510L in healthy male volunteers) and is highly bound (99.5%) to plasma proteins, including albumin, α-1-acid glycoprotein, γ-globulin and lipoproteins.A pharmacologically inactive acylglucuronide conjugate, which comprised 16% of the drug in circulation after a single 40mg dose, is the only metabolite of telmisartan. The pharmacokinetics of orally administered telmisartan are nonlinear over the dose range 20 to 160 mg, with greater than proportional increases of plasma concentrations (C max and AUC) with increasing doses. Combination treatment with telmisartan and hydrochlorothiazide in black patients with mild to moderate hypertension. It was significantly more effective than placebo in large (n >100), double-blind, randomised, multicentre clinical trials in patients with mild to moderate hypertension. Am J Ther. J Hypertens 2000 Jun; 18 Suppl. Furthermore, telmisartan produced a significantly lower incidence of dry cough than lisinopril in patients with a history of ACE inhibitor-related cough in a study for which this parameter was the primary end-point (15.6 vs 60%; p … Am J Hypertens 2001 Apr; 14 (4 Pt 2): 114AMattioli AV, Fortanesi L, Vandelli R, et al. N Engl J Med 1973 Aug 2; 289(5): 249–52Meredith PA. Telmisartan was given as a single oral (1 – 160 mg) or intravenous (10 – 160 mg) dose to young males. BMJ 1999 Sep 4; 319: 630–5Kolloch RE, Neutel JM, Plouin PF. <>stream 3: S59-62Boehringer Ingelheim. Telmisartan 40 mg/day reduced arterial stiffness in patients with type 2 diabetes mellitus and hypertension in a randomised, double-blind, placebo-controlled, 3-week, crossover study.During 9 months of treatment with telmisartan 40 or 80 mg/day, blood pressure and left ventricular (LV) mass index were significantly reduced compared with baseline in patients with hypertension and mild to moderate LV hypertrophy. Prospective randomized open blinded end-point (PROBE) study. J Clin Pharmacol 2000; 40: 1365–72Stangier J, Su C-APF, Schöndorfer G, et al. The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Int J Clin Pract 1999; 53: 99–103Elliot HL. J Clin Pharmacol 2000; 40: 1323–30Guidelines Subcommittee of the World Health Organization — International Society of Hypertension. J RAAS 2001 Mar; 2(1): 63Asmar R, Gosse P, Topouchian J, et al. J Clin Pharmacol 2000; 40: 1380–90Burgess ED, Buckley S. Acute natriuretic effect of telmisartan in hypertensive patients [abstract]. Effects of the AT1-selective angiotensin II antagonist, telmisartan, on hemodynamics and ventricular function after cardiopulmonary resuscitation in pigs. Pharmacotherapy 2000; 20(2): 130–9Oparil S. Newly emerging pharmacologic differences in angiotensin II receptor blockers. (Data on file)Song JC, White CM. Eur J Clin Pharmacol 1998 Aug; 54(6): A12Stangier J, Su C-APF, Fraunhofer A, et al.Pharmacokinetics of acetaminophen and ibuprofen when coadministered with telmisartan in healthy volunteers. Assess the comparative efficacy and safety of telmisartan on the clinical pharmacology of glibenclamide healthy! The novel nonpeptide angiotensin II receptors in the presence and absence of telmisartan its. Bibr277, an ATWagner J, Drab M, Lee MA, Kreutz R, Gosse P et! The metabolite of telmisartan compared to atenolol at relative low fixed doses abstract. 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