For tretinoin, scientists have created the largest variety of formulations, which include gels, microsphere gels, polymers, and the newly created nanogel, which is not yet commercially available. Patients tolerated 0.1% tazarotene and 0.025% tretinoin treatment less than that of adapalene. This nighttime formula is an ideal starter retinol, both for your retinoid-virgin skin and your budget.If there's anyone who loves retinol as much as dermatologists, it's aestheticians like Shani Darden. One of the newest vehicles to be developed is that of a tretinoin nanogel, which is not yet commercially available. Patients taking retinoids for acne should be aware that each of these options provides for differing levels of reduction in acne lesions and intensity of side effects. Suspended in the mix are retinol and the vitamin-A derivative retinyl propionate. Irritation may also be aggravated by exposure to wind, cold, sunlight or use of soaps, cleansers, astringents, exfoliants and certain cosmetics. However, studies independently investigating the effectiveness of microsphere gel have been consistent with results from previously performed studies using the traditional gel, suggesting that efficacy is similar between the two vehicles.Scientists developed the tretinoin polymer vehicle, like the tretinoin microsphere gel, to release tretinoin in a slow, controlled fashion in hopes that this would reduce skin irritation.Scientists continue to develop new vehicles for retinoids in order to increase efficacy and decrease side effects. Comparing the multitude of options is difficult, because there are no studies that examine the effectiveness of all three retinoids with all of their potential concentrations and vehicles. Scientists have focused their efforts on studying tretinoin vehicles within retinoid formulations, and have deduced that the tretinoin nanogel may be a better option, whereas the tretinoin microsphere gel is perhaps going in the wrong direction. And from the research thus far, it appears that tretinoin and adapalene produce similar results. While many pros dismiss it as a do-nothing derivative that's too far back in the conversion chain to deliver a usable amount of vitamin A, the company claims it serves to boost the HPR, making it work even better. One review compiled 34 independent studies to examine and compare side effects after tretinoin, adapalene, and tazarotene treatment. As Dobos explains, "The retinol is only released when rubbed into the skin;" the encapsulation keeps the notoriously unstable vitamin fresh and protected up until that moment. But there have been several studies that at least compare two of them head-to-head, so here is our best educated guess based on the data so far:Tazarotene may be slightly more effective compared to Adapalene, and Adapalene may be similarly effective compared to Tretinoin.Tolerability is also very important when it comes to choosing a topical retinoid, and we get a different view of things when we look at topical retinoids from this lens:Tazarotene comes with the most severe side effects, Tretinoin has less, and Adapalene has even less.Topical retinoids are derivatives of vitamin A that treat mild-to-moderate acne. Our tester loved its luxe vibe as much as the early returns: smoother, fresher-looking skin in only two weeks. A relatively affordable retinol option, this cream's key ingredient is surrounded by a virtual garden of botanical ingredients. The first retinoid approved for patient use was tretinoin, which doctors began prescribing for the treatment of acne in 1971. 1 Since then, scientists developed two additional retinoids in the 1990s, called adapalene and tazarotene, which are now also FDA-approved for acne treatment. They found that all retinoids, regardless of concentration, induced some level of skin reaction within a subset of their examined subjects during the first two to four weeks. "Due to these differences, the FDA has approved different concentrations of each retinoid. If your skin is normal and not overly sensitive, tazarotene--while it may cause you more side effects in the first two to three months of treatment--may ultimately be most effective in reducing your acne.Acne.org does not advertise. While 1 percent retinol is no joke, a slow-release delivery system and a squad of soothing extracts exert a serious calming influence. There are three FDA-approved prescription topical retinoids on the market:No studies have yet been performed directly comparing all three retinoids at once, so we can't say for sure.