Table 2: Common Adverse Reactions Occurring in ≥ 2% of Trazodone Hydrochloride -treated Patients and Greater than the Rate of Placebo-Treated Patients as Observed in Controled Clinical Studies[see Warnings and Precautions ( Advise patients that there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Trazodone hydrochloride tablets during pregnancy Trazodone Hydrochloride (traz' oh done hye'' droe klor' ide) Tablets, for oral useWhat is the most important information I should know about Trazodone hydrochloride tablets?Call a healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you:What else do I need to know about antidepressant medicines?Never stop an antidepressant medicine without first talking to a healthcare provider.Antidepressants are medicines used to treat depression and other illnesses.Antidepressant medicines can interact with other medicines.Before you take Trazodone hydrochloride tablets tell your healthcare provider about all of your medical conditions, including if you:Tell your healthcare provider about all the medicines you take,What are the possible side effects of Trazodone hydrochloride tablets?Trazodone hydrochloride tablets can cause serious side effects or death, including:See “What is the most important information I should know about Trazodone hydrochloride tablets?”Irregular or fast heartbeat or faint (QT prolongation)Feeling high or in a very good mood, then becoming irritable, or having too much energy, feeling like you have to keep talking or do not sleep (mania).The most common side effects of Trazodone hydrochloride tablets include:General information about the safe and effective use of Trazodone hydrochloride tablets.What are the ingredients in Trazodone hydrochloride tablets?We comply with the HONcode standard for trustworthy health information - 16729-300-17, Priapism, if not treated promptly, can result in irreversible damage to the erectile tissue. Counsel family members or caregivers of patients to monitor for changes in behavior and to alert the healthcare provider. If it is necessary to initiate treatment with an MAOI such as linezolid or intravenous methylene blue in a patient taking Trazodone hydrochloride tablets, discontinue Trazodone hydrochloride tablets before initiating treatment with the MAOI Monitor all patients taking Trazodone hydrochloride tablets for the emergence of serotonin syndrome. It may harm them. Avoid use of antidepressants, including trazodone hydrochloride, in patients with untreated anatomically narrow angles.Hyponatremia may occur as a result of treatment with SNRIs and SSRIs, including trazodone hydrochloride. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency or establish a causal relationship to drug exposure:To report SUSPECTED ADVERSE REACTIONS contact AvKARE at 1-855-361-3993; email drugsafety@avkare.com; or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.The concomitant use of MAOIs and serotonergic drugs including Trazodone hydrochloride tablets increases the risk of serotonin syndrome.Trazodone hydrochloride tablets are contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue isocarboxazid, moclobemide, phenelzine, selegiline, tranylcypromineThe concomitant use of serotonergic drugs including Trazodone hydrochloride tablets and other serotonergic drugs increases the risk of serotonin syndrome.Monitor patients for signs and symptoms of serotonin syndrome, particularly during Trazodone hydrochloride tablets initiation. Peak plasma levels occur approximately one hour after dosing when trazodone hydrochloride is taken on an empty stomach or 2 hours after dosing when taken with food.In some patients trazodone may accumulate in the plasma.Trazodone is 89 to 95% protein bound Si raccomanda di chiedere sempre il parere del proprio medico curante e/o di specialisti riguardo qualsiasi indicazione riportata. Take your next dose at the regular time. The concurrent use of an antiplatelet agent or anticoagulant with Trazodone hydrochloride tablets may potentiate the risk of bleeding.Inform patients of the increased risk of bleeding with the concomitant use of Trazodone hydrochloride tablets and antiplatelet agents and anticoagulants. 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