any on board meds other than tylenol and. This is the 2nd time my mom has taken Tylenol arthritis every day for pain on her doctorâs recommendation, and both times, her INR went up from normal range 2.4 to out of range 3.4. This is the 2nd time my mom has taken Tylenol arthritis every day for pain on her doctor’s recommendation, and both times, her INR went up from normal range 2.4 to out of range 3.4. These medications may cause some risk when taken together. May 18, 2011. I take Coumadin for a heart valve. These medicines may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. My INR was 5. What can I take for pain relief?How much is two grams of acetaminophen? It shows that physicians donât know all the effects of drugs. Last time, it went to 3.7. Contact your healthcare professional (e.g. Talk with the doctor before giving Tylenol Arthritis Pain (acetaminophen controlled-release tablets) to a child. So not sure if Tylenol alone or the combination is the problem. Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle. This information is generalized and not intended as specific medical advice. Do not start, stop, or change the dosage of any medicine before checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc. I have had a cold this week with headache and bodyaches. I fell and fractured my sternum. I feel like dropping the warfarin so I could treat my pain, but that isnât an option. We understand how cautious you must be at monitoring your INR values to prevent hemorrhage on the one hand or a blood clot on the other.Other visitors to The Peopleâs Pharmacy website have shared their frustration about acetaminophen (Tylenol) and warfarin.âI have been on Coumadin for the last few months for an Afib condition. Tell care providers that you take warfarin before you have any medical or dental procedures. Stop use and ask a doctor if. In these subjects, celecoxib did not alter the anticoagulant effect of warfarin as determined by prothrombin time. I was placed on Coumadin 3 months ago and was simultaneously taken off of anti-inflammatory drugs that I was on for years for bilateral knee osteoarthritis and PRN anti-inflammatories for gouty arthritis flares. doctor or pharmacist) know that you are taking these medicines together, how often you take acetaminophen, and how much acetaminophen you take. I took Tylenol for the pain not knowing the interaction.âI was of town and had to go the ER because the pain did not subside, and I had black and blue marks on my body. Recommendations regarding the management of patients taking both drugs are not strong because no studies examining outcomes, such as major bleeding, exist. Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin. So Iâm stuck between a rock and a hard place. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. “I agree the Tylenol is definitely not compatible with warfarin. Maybe one now and then only.âShare your own acetaminophen (Tylenol) and warfarin story below in the comment section.Join our daily email newsletter with breaking health news, prescription drug information, home remedies AND you'll get a copy of our brand new full-length health guide â for FREE!We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options.Acetaminophen is perceived as super safe. They stopped the Coumadin for two days and gave me another pain med, Norco [an opioid].âWell, my INR returned to a normal value of 2.4, and I am recovering from the fractured bone. Thromb Haemost 2004 Oct;92(4):797-802. To date, none of my caregivers will support any on board meds other than tylenol and narcotics.