Amlodipine and valsartan work in different ways to relax your blood vessels, which helps to lower your blood pressure. Click on the desired brand to find out the drug price or cost of the drug. The incidence of adverse events in the elderly with amlodipine + valsartan (37.5%) was similar to that observed with amlodipine monotherapy (35.8%) and lowest with valsartan monotherapy and placebo (both, 25.9%). All rights reserved. In this study population, the combination of amlodipine + valsartan was well tolerated; the incidence of adverse events overall was 44.1% with combination therapy compared with 39.8% with valsartan monotherapy, 45.7% with amlodipine, and 38.3% with placebo. Safety was assessed by monitoring and recording all reported adverse events, as well as monitoring changes in clinical laboratory test results, physical examinations, and vital signs.Subgroup analyses were performed based on the stage of hypertension, age, and race. MedicineNet does not provide medical advice, diagnosis or treatment. This trend was observed for all treatment groups. As a result, amlodipine relaxes the blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload. If you take one of these drugs, your doctor will monitor you closely and adjust your dosage if needed.Amlodipine/valsartan can cause a severe allergic reaction. Symptoms of low blood pressure can include dizziness or feeling faint, or chest pain. or greater. effect is seen within 2 weeks.Combining valsartan with potassium-sparing diuretics To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.Examples of drugs that can cause interactions with amlodipine/valsartan are listed below.Using certain heart drugs with amlodipine/valsartan raises your risk of very low blood pressure and increased potassium levels. Our website services, content, and products are for informational purposes only. If your symptoms are severe, call 911 or go to the nearest emergency room right away.Keep these considerations in mind if your doctor prescribes amlodipine/valsartan for you.A prescription for this medication is refillable. Nov. 27, 2018 -- Two more valsartan blood pressure drugs have been recalled because of impurities in its key ingredient. triple therapy with valsartan, amlodipine and hydrochlorothiazide reduced blood pressure more than any of the dual therapy combinations. Examples of these drugs include:In people who are older or have kidney problems, the use of this medication along with NSAIDs (nonsteroidal anti-inflammatory drugs) can cause serious kidney damage. Baseline mean sitting BPs were 152.8/99.3 mm Hg in study 1 and 156.7/99.1 mm Hg in study 2.Stage 2 hypertension was identified in 53.8% (1029 of 1911) of patients in study 1 and 61.0% (763 of 1250) of patients in study 2. Amlodipine is a calcium channel blocker (CCB). Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency MedicineWhat is amlodipine and valsartan, and how does it work (mechanism of action)?What are the side effects of amlodipine and valsartan?Which drugs or supplements interact with amlodipine and valsartan?Is amlodipine and valsartan safe to take if I'm pregnant or breastfeeding?What else should I know about amlodipine and valsartan? Angiotensin II-receptor antagonists have similar blood pressure reducing effects to those of other major antihypertensive drug classes. measured. 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