It also really Medications such as brexpiprazole have been shown to have a lower risk of TD compared to older antipsychotics, such as Haldol® (haloperidol). Symptoms include confusion, fever, extreme muscle stiffness, and sweating. It is the brand name of a drug called brexpiprazole that works by rebalancing serotonin and dopamine levels to improve mood, thinking and behavior. There may be variations in CSA schedules between individual states.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drug interactions are reported among people who take Rexulti and Viibryd together. … I talked to my … If it works really well for people they don't tend to return to review as they are busy enjoying there lives. Brexpiprazole rebalances dopamine and serotonin to improve thinking, mood, and behavior.Brexpiprazole may help some or all of these symptoms.Brexpiprazole is also FDA approved for the following indications:This medication sheet will focus primarily on schizophrenia. 3 DOSAGE FORMS AND STRENGTHS VIIBRYD Tablets are available as 10 mg, 20 mg and 40 mg film-coated tablets. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. 0. The first few days taking it I had kind of migraine like symptoms, very tired, but just plan accordingly and know that will all most likely pass. Medicines like REXULTI can raise the risk of death in elderly who have lost touch with reality due to confusion and memory loss . My Grandfather and my Father suffered from Depression. In a way I think this drug brings out some negative thoughts for me in the 3-4 hours after taking it. It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com. 0 thank. It’s a good combo for me. The study is created by eHealthMe based on reports of 114 people who take Rexulti and Viibryd from the FDA, and is updated regularly. I felt better within a couple of days. 10 mg PO qDay for 7 days with food; THEN increase to 20 mg qDay with foodMay increase further up to 40 mg/day after a minimum of 7 days between dosage increasesGradually taper dose , upon discontinuation of antidepressant, to minimize withdrawal symptoms and allow for detection of re-emerging symptoms; in patients taking 40 mg/day, taper dose to 20 mg qDay for 4 ddays; follow by reducing dose to 10 mg qDay for 3 days; if patient is taking 20 mg/day, taper dose to 10 mg qDay for 7 daysRenal impairment (mild/moderate/severe): No dose adjustment recommendedHepatic impairment (mild/moderate/severe): No dose adjustment recommendedPrior to initiating, screen patients for a personal or family history of bipolar disorder, mania, or hypomaniaGeneral disorders and administrative site conditions: IrritabilityPsychiatric disorders: Hallucinations, suicide attempt, suicidal ideationIncreased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants for major depressive disorder and other psychiatric disordersIn children and young adults, the risks must be weighed against the benefits of taking antidepressantsPatients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during the initial 1-2 months of therapy, as well as during dosage adjustmentsThe patient’s family should communicate any abrupt changes in behavior to the healthcare providerWorsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapyMay worsen psychosis in some patients or cause a shift to mania or hypomania in bipolar disorder; patients should be screened for bipolar disorder prior to the initiation of therapyMay precipitate mixed/manic episode if initiated for bipolar disorderMay cause serotonin syndrome or neuroleptic malignant syndrome-like reactions, including agitation, hallucinations, coma, autonomic instability (eg, tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (eg, hyperreflexia, incoordination), and/or gastrointestinal symptoms (eg, nausea, vomiting, diarrhea)Use with caution in patients with history of seizures; has not been systematically evaluated in patients with seizure disorders (caution advised)Serotonin reuptake inhibition may increase risk of bleeding (caution with drugs that inhibit platelets or coagulation)Decrease dose gradually when discontinuing, to avoid dysphoric mood, irritability, insomnia, agitation, and confusionCYP3A4 (major substrate); CYP2C19 (minor substrate, minor inhibitor, minor inducer); CYP2D6 (minor substrate, minor inhibitor); CYP2C8 (moderate inhibitor); increased plasma concentration (by 50%) observed when coadministered with strong CYP3A4 inhibitors (eg, ketoconazole)Highly bound to plasma proteins (administration to patient taking another drug that is highly protein bound may increase free concentrations of the other drug)Hyponatremia has been reported with other SSRIs, and SNRIs; common adverse effects include diarrhea, nausea, xerostomia, dizziness, and insomnia; can occur in association with syndrome of inappropriate antidiuretic hormone secretion (SIADH)Bone fractures reported with antidepressant treatment; consider possibility of fragility fracture if antidepressant treated patient presents with unexplained bone pain, swelling, point tenderness, or bruising;Coadministration with 5HT receptor agonist (ie, triptan), other serotonergic drugs (eg, SSRIs, SNRIs, buspirone, tramadol), or antidopaminergic drugs may increase risk for serotonin syndromeConcomitant use with serotonin precursors (eg, tryptophan) not recommendedSerotonin reuptake inhibition may increase risk of bleeding (caution when coadministered with aspirin, NSAIDs, warfarin, and other anticoagulants)Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomyThere is conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (PPHN; see Pregnancy)Write prescription for smallest quantity consistent with good patient careAbrupt discontinuation or interruption of therapy associated with discontinuation syndrome; antidepressants with shorter half-lives, prolonged treatment, or abrupt discontinuation, associated with increased risk of developing discontinuation syndrome; for antidepressants of short of intermediate hslf-lives, symptoms may emerge within 2-5 days after treatment discontinuation; may last 7-14 daysThere is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antidepressants during pregnancyHealthcare providers are encouraged to register patients by calling the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at There are no adequate and well-controlled studies in pregnant women; a prospective, longitudinal study followed 201 pregnant women with a history of major depressive disorder who were euthymic and taking antidepressants at beginning of pregnancy; women who discontinued antidepressants during pregnancy were more likely to experience a relapse of major depression than women who continued antidepressants; consider the risks of untreated depression when discontinuing or changing treatment with antidepressant medication during pregnancy and postpartumExposure in late pregnancy may lead to increased risk for neonatal complications requiring prolonged hospitalization, respiratory support, and tube feeding, and/or persistent pulmonary hypertension of the newborn (PPHN); monitor neonates who were exposed to therapy in third trimester of pregnancy for PPHN and drug discontinuation syndromeThere are no data on presence in human milk, effects on breastfed infant, or on milk production; however, drug is excreted in rat milk; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from drug or from underlying maternal conditionA: Generally acceptable.