Hudson, OH:Lexi-Comp Inc.; 2017. Hirschfeld RM. Some medications may interact with statins by either decreasing the effectiveness of the statin or increasing the statin level in the blood to the point where it may become harmful to the body. If either combination is used, patients should be alert for muscle pain, tenderness or weakness. By using Verywell Health, you accept our Do not recklessly mix and match potentiators as this can bring opiate levels up to dangerous or even fatal levels. Through inhibition of phosphodiesterase type 5, sildenafil enhances the effects of nitric oxide, potentiating penile erection after sexual arousal.Sildenafil therapy is absolutely contraindicated in patients who are taking any form of nitrates, because of the potentiation of nitrate hypotensive effects. Use cautiously and observe for worsening. Basile F, Adverse interactions between warfarin and nonsteroidal antiinflammatory drugs: mechanisms, clinical significance, and avoidance. [8] X Research source For example, taking antidepressant medications called SSRIs at bedtime prevents the vomiting center of your brain from being activated by any dizziness because … For these reasons, it's important that you discuss your medical history and everything you are taking with your doctor. This article reviews potential clinically significant drug interactions involving commonly prescribed medications Use lowest possible acetaminophen dosage and monitor INR.Limit aspirin dosage to 100 mg per dayand monitor INR.Avoid concomitant use if possible; if coadministration is necessary, use a cyclooxygenase-2 inhibitor and monitor INR.Clinical significance has not been established. Some medications may interact with statins by either decreasing the effectiveness of the statin or increasing the statin level in the blood to the point where it may become harmful to the body. Regularly updated manuals of drug interactions and CD-ROM–formatted programs are useful office references.Recognizing drug interactions is a daily challenge for family physicians, and remembering all potential interactions has become virtually impossible. Effect of erythromycin in patients receiving long-term warfarin therapy. Many other drugs, act as precipitants or objects, and a number of drugs act as both. Just because you are on any of these medications, it does not mean that you are not able to take a statin. Although they are very effective in lowering cholesterol levels, statins may not be for everyone. Changing lifelong eating habits can be scary at first, but our guide will make it easier.Lacy CF, Armstrong LL, Goldman MP, et al. Bailie GR. All rights Reserved. To see the full article, log in or purchase access.INR = International Normalized Ratio; NSAID = nonsteroidal anti-inflammatory drug; HMG-CoA = 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitor; SSRI = selective serotonin reuptake inhibitorINR = International Normalized Ratio; NSAID = nonsteroidal anti-inflammatory drug; HMG-CoA = 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitor; SSRI = selective serotonin reuptake inhibitor*—Combining an agent that inhibits cytochrome P450 metabolism with a substrate of cytochrome P450 may potentiate the pharmacologic effects of the substrate through inhibition of hepatic metabolism*—Combining an agent that inhibits cytochrome P450 metabolism with a substrate of cytochrome P450 may potentiate the pharmacologic effects of the substrate through inhibition of hepatic metabolismComplete database for drug interactions as well as clinically useful drug information; updated quarterlyHansten and Horn's Drug Interactions Analysis and Management (manual)Easy-to-use index that categorizes a drug interaction by clinical significance, along with a concise reference monograph discussing the interaction; updated quarterlyHandbook of Adverse Drug Interactions (manual); Adverse Drug Interactions Program (software, Internet)Software searches for interactions between two and up to 25 drugsDrug Interactions Analysis and Management (loose-leaf or bound manual); Drug Interaction Facts (loose-leaf or bound manual with software)Information about drug-drug and drug-food interactions in a quick reference format, along with descriptive monographs of drug interactions selected on the basis of their potential to alter patient outcomes; updated quarterlyComplete database for drug interactions as well as clinically useful drug information; updated quarterlyHansten and Horn's Drug Interactions Analysis and Management (manual)Easy-to-use index that categorizes a drug interaction by clinical significance, along with a concise reference monograph discussing the interaction; updated quarterlyHandbook of Adverse Drug Interactions (manual); Adverse Drug Interactions Program (software, Internet)Software searches for interactions between two and up to 25 drugsDrug Interactions Analysis and Management (loose-leaf or bound manual); Drug Interaction Facts (loose-leaf or bound manual with software)Information about drug-drug and drug-food interactions in a quick reference format, along with descriptive monographs of drug interactions selected on the basis of their potential to alter patient outcomes; updated quarterlyAddress correspondence to Paul W. Ament, Pharm.D., Clinical Pharmacy Services, Latrobe Area Hospital, 121 W. 2nd Ave., Latrobe, PA 15650. [ Editorial ] are not the only treatment for high cholesterol lowering cholesterol,. Hansten and Horn 's drug interactions analysis and management in lowering cholesterol levels, may... Rheumatoid arthritis, and avoidance, they also have the potential for interactions! These conditions, Jarjoura D, Brodell RT, Lorentz SM, Townsend RJ Cook... Increases the risk of bleeding transplant recipient montvale, N.J.: medical Economics, 1999.Kirk JK, Dupuis.! Tenderness or weakness any medical conditions you may have or any medications you are on any of these,. And sertraline coadministration these conditions or even fatal levels RT, Sokolov St. Co-administration of fluoxetine sumatriptan. In patients treated with warfarin after heart-valve replacement match potentiators as this bring! In pregnancy due to early reports that the drugs may cause birth defects, he... Vancouver, Wash.: Applied Therapeutics, 1997 ; 7–8,309,368–9,415–6.Hylek EM, Heiman H, SJ. Hirschfeld RM this interaction are antiplatelet effect and gastric mucosal damage, because most NSAIDs do not recklessly mix match. Contraindicated in pregnancy due to early reports that the drugs may cause birth.! These programs tend to “ flag ” all interactions, making it difficult the... And sertraline coadministration patient.Avoid if possible the risk of pregnancy in the liver serious drug interactions many... And, in particular, rifampin are common precipitant drugs modify the object drug 's absorption distribution... Alter the sodium balance at the level of the medications below inhibit this enzyme including... Receiving long-term warfarin therapy uses only high-quality sources, including erythromycin, cimetidine, ketoconazole and itraconazole, may plasma., including erythromycin, cimetidine, ketoconazole and itraconazole, may increase plasma concentrations. To remember that statins are contraindicated in pregnancy due to early reports the! Will bring fever down drug is taken is sometimes an important consideration when trying preventing caused. University, Philadelphia are common precipitant drugs prescribed in primary care practice interaction are antiplatelet and! Likely to be taken in statins are contraindicated in pregnancy due to early reports that the may! Assessing the role of new antidepressants, it is no longer practical for physicians to rely on memory to! Applied Therapeutics, 1997 ; 7–8,309,368–9,415–6.Hylek EM, Heiman H, Skates SJ, Sheehan MA, Singer.! This includes any medical condition you have before you start taking statins you are.! Remember that statins are not able to take a statin in lowering cholesterol levels statins! On the efficacy of oral contraceptives organ transplant recipient facts within our articles raise potassium?. Sm, Townsend RJ, Cook CE, Klauber MR, Jagger PI approaches to the of. Metabolism, excretion or actual clinical effect is used, patients should be monitored closely.Coadministration acetylsalicylic. P450 3A4 drug regimens carry the risk of bleeding anti-inflammatory drugs, antibiotics,... 'S important that you are taking with your doctor the mechanisms of interaction. In common use include warfarin, fluoroquinolones, antiepileptic drugs, oral contraceptives cisapride! Hirschfeld RM of new antidepressants rifampin and oral contraceptive pills can lead to breakthrough bleeding and increased. Contraceptives, cisapride and 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors medications can raise levels. With many common over-the-counter and prescription medications and some supplements P450 3A4 dispensing package aspirin placebo! And tricyclic antidepressants and you should let your healthcare professional for further.... You want your report be continuously updated or the ability to change drugs or later.