Some people lose weight when taking Dostinex, which might be due to side effects. My weight is creeping up (around 1.5 kilos). Put on 20 lbs in six months. Studies in lean and obese subjects and during short-term fastingDecreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistanceCerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans I also know that if having to pee wakes you up too much during the night, eating more salt can help (it just means you'll store extra water in your tissue instead of your bladder). Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. I have PV and since starting Hydroxyurea 9 months age I have put on 7 pounds. Also, chapped lips and dry eyes told me something was taking my water. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. When I noticed that I'm gaining weight I was in panic. xI started on Hu a couple months ago. Not sure if this is all due to the Hydroxyurea or my thyroid issues. Whether that’s in people with myelofibrosis who have lost weight related to the disease, even if they’re on hydroxyurea, they don’t tend to gain some of that weight back. Don't know how to lose the weight.Have been taking hydroxycarbamide for 6 months and have started to put weight on and have minor nosebleeds, anyone else ?Maybe as we get so tired and sit and relax more so we can cope, the answer might be we have an extra cuppa with just another biscuit!!! Any thoughts! If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Women must use birth control while taking hydroxyurea capsules 500 mg and for some time after the last dose. But in reading one of the other reviews...I don't drink as much water as I probably should. If somebody have some seggestions I would be happy to hear it.Hi interesting to hear re weight gain, I wonder if thats why they weigh me each time I go. Share the link to this question. I have been on it 10 months and have...Has anyone put a lot of weight on with hydroxycarbamide. Diarrhea 3. I'll also add some 'apple cider vinegar' to the water as heard that assists in losing weight. I can only suggest one thing - drink plenty of water!! 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